Risk factors and mortality rates of carbapenem-resistant Gram-negative bacterial infections in intensive care units  

作　　者：Tulay Orhan Kuloglu Gamze Kalin Unuvar Fatma Cevahir Aysegul Ulu Kilic Emine Alp 

机构地区：[1]Infection Control Committee,Faculty of Medicine,Erciyes University,Kayseri,Turkey [2]Department of Infectious Diseases,Faculty of Medicine,Erciyes University,Kayseri,Turkey [3]Programme of First and Emergency Aid,Sakarya University,Sakarya,Turkey [4]Department of Infectious Diseases,Faculty of Medicine,Yıldırım Beyazıt University,Ankara,Turkey

出　　处：《Journal of Intensive Medicine》2024年第3期347-354,共8页重症医学（英文）

摘　　要：Background The prevalence of hospital-acquired infections caused by carbapenem-resistant gram-negative bacteria(CRGNB)is increasing worldwide.Several risk factors have been associated with such infections.The present study aimed to identify risk factors and determine the mortality rates associated with CRGNB infections in intensive care units.Methods This retrospective case-control study was conducted at Erciyes University Hospital(Kayseri,Turkey)between January 2017 and December 2021.Demographic and laboratory data were obtained from the Infection Control Committee data and record system.Patients who had CRGNB infection 48–72 h after hospitalization were assigned to the case group,while those who were not infected with CRGNB during hospitalization formed the control group.Risk factors,comorbidity,demographic data,and mortality rates were compared between the two groups.Results Approximately 1449 patients(8.97%)were monitored during the active follow-up period;of those,1171 patients were included in this analysis.CRGNB infection developed in 14 patients(70.00%)who had CRGNB colonization at admission;in 162(78.26%)were colonized during hospitalization,whereas 515(54.56%)were not colonized.There was no significant difference in age,sex(male/female)or comorbidities.The total length of hospital stay was statistically significantly longer(P=0.001)in the case group(median:24[interquartile range:3–378]days)than the control group(median:16[interquartile range:3–135]days).The rates of colonization at admission(25.5%;vs.10.6%,P=0.001)and mortality(64.4%vs.45.8%,P=0.001)were also significantly higher in the cases than in the control group,respectively.In the univariate analysis,prolonged hospitalization,the time from intensive care unit admission to the development of infection,presence of CRGNB colonization at admission,transfer from other hospitals,previous antibiotic use,enteral nutrition,transfusion,hemodialysis,mechanical ventilation,tracheostomy,reintubation,central venous catheter,arterial catheterization,chest

关 键 词：Multidrug resistance Gram-negative bacteria INFECTION Intensive care units 

分 类 号：R459.7[医药卫生—急诊医学]