腹外侧中脑导水管周围灰质调控疼痛的神经环路机制研究进展  

Research advances on the neural circuit mechanism of pain regulation in the ventrolateral periaqueductal gray

作　　者：王欣 刘程曦 张益 Wang Xin;Liu Chengxi;Zhang Yi(Department of Anesthesiology,the Second Affiliated Hospital of Zunyi Medical University,Zunyi 563006,China;Department of Anesthesiology,the Second Affiliated Hospital of the University of South China,Hengyang 421001,China)

机构地区：[1]遵义医科大学第二附属医院麻醉科,遵义563006 [2]南华大学附属第二医院麻醉科,衡阳421001

出　　处：《国际麻醉学与复苏杂志》2024年第6期656-660,共5页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金(82301447);贵州省科技计划项目(黔科合基础‑ZK[2022]一般597);湖南省自然科学基金——青年基金项目(2022JJ40397);遵义医科大学研究生科研基金(ZYK253)。

摘　　要：腹外侧中脑导水管周围灰质(vlPAG)位于中脑导水管周围灰质(PAG)的腹外侧区域,其含有丰富的γ-氨基丁酸能、谷氨酸能、多巴胺能等神经元及5-羟色胺(5-HT)、谷氨酸、γ-氨基丁酸、乙酰胆碱等神经化学物质,与大脑众多区域都有神经纤维连接,是脑内参与疼痛调节的重要脑区。文章综述了vlPAG的结构组成特点,vlPAG参与疼痛调节的神经生理机制及其与大脑其他区域的神经纤维联系,总结了其在疼痛调控中的关键作用,为研发更多相关镇痛药物及方法提供依据和思路。The ventrolateral periaqueductal gray matter(vlPAG)is located in the ventrolateral region of the periaqueductal gray matter(PAG)of the midbrain,which includes γ-aminobutyric acidergic neurons,glutamatergic neurons,and dopaminergic neurons.It contains neurochemicals such as 5-hydroxytryptamine(5-HT),glutamate,γ-aminobutyric acid,and acetylcholine.The vlPAG has nerve fiber connections to many areas of the brain and is an important brain region involved in pain regulation.This article reviews the structural characteristics of vlPAG,the neurophysiological mechanism of vlPAG involved in pain regulation,and its connection with nerve fibers in other brain regions,and summarizes its key role in pain regulation,so as to provide basis and ideas for the development of more related analgesic drugs and methods.

关 键 词：腹外侧中脑导水管周围灰质 疼痛 镇痛 Γ-氨基丁酸能神经元 谷氨酸能神经元 神经回路 

分 类 号：R614[医药卫生—麻醉学]