巴彦淖尔地区老年人群维生素B12缺乏与血脂异常的关系  

Relationship between vitamin B12 deficiency and dyslipidemia in elderly population in Bayannaoer region

作　　者：邬姣 侯玥 Wu Jiao;Hou Yue(Department of Clinical Laboratory,Bayannaoer Hospital,Bayannaoer 015000,Inner Mongolia Autonomous Region,China)

机构地区：[1]巴彦淖尔市医院检验科,内蒙古自治区巴彦淖尔015000

出　　处：《实用检验医师杂志》2024年第2期176-178,共3页Chinese Journal of Clinical Pathologist

摘　　要：目的 探讨内蒙古自治区巴彦淖尔地区老年人群维生素B12(VB12)缺乏与血脂异常的关系。方法 收集2021年1月—2024年2月在巴彦淖尔市医院老年病科就诊且年龄> 60岁的477例患者的临床资料,包括血清VB12、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。根据血清VB12水平不同将患者分为正常组(331例)和缺乏组(146例),分析并比较不同年龄段、不同性别患者以及其他因素(是否合理饮食、是否缺乏锻炼、是否患其他疾病)条件下血清VB12以及血脂指标水平差异;采用Pearson相关性分析法评估VB12与TC、TG、HDL-C、LDL-C的相关性。结果 两组性别、年龄及其他因素比较差异均无统计学意义。与正常组比较,缺乏组的TC水平显著升高,TG和HDL-C水平均显著降低[TC(mmol/L):3.22±1.37比2.44±1.66;TG(mmol/L):2.12±1.24比2.85±1.57;HDL-C(mmol/L):1.31±0.73比1.93±0.87;均P <0.05],正常组与缺乏组的LDL-C水平比较差异无统计学意义(mmol/L:1.75±0.89比2.31±0.89,P> 0.05)。VB12与年龄、TG、HDL-C均呈正相关(r值分别为0.108、0.102、0.128,P值分别为0.002、0.002、0.001),与TC、LDL-C均呈负相关(r值分别为-0.091、-0.103,P值分别为0.007、0.003)。结论 巴彦淖尔地区老年群体血清VB12缺乏是引起血脂异常的因素之一。Objective To investigate the relationship between vitamin B12(VB12)and dyslipidemia in elderly population in Bayannaoer,Inner Mongolia Autonomous Region.Methods The clinical data of 477 patients over 60 years old admitted to geriatric department of Bayannaoer Hospital from January 2021 to February 2024 were collected,including serum VB12,total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C).The patients were divided into normal group(331 cases)and deficient group(146 cases)according to the level of serum VB12.The levels of serum VB12 and blood lipid indicators were compared in different age groups,different genders,and under other conditions(whether with balanced diet,lacked exercise or with other diseases).The correlation between VB12 and TC,TG,HDL-C,LDL-C was evaluated by Pearson correlation analysis.Results There were no significant differences in gender,age or other factors between two groups.Compared with normal group,the level of TC in deficiency group was increased,and the levels of TG and HDL-C were reduced[TC(mmol/L):3.22±1.37 vs.2.44±1.66;TG(mmol/L):2.12±1.24 vs.2.85±1.57;HDL-C(mmol/L):1.31±0.73 vs.1.93±0.87;all P<0.05].There was no statistically significant difference in LDL-C levels between normal group and deficient group(mmol/L:1.75±0.89 vs.2.31±0.89,P>0.05).VB12 were positively correlated with age,TG,HDL-C(r values were 0.108,0.102,0.128,P values were 0.002,0.002,0.001),and negative correlated with TC,LDL-C(r values were-0.091 and-0.103,P values were 0.007 and 0.003).Conclusion The deficiency of serum VB12 in elderly population in Bayannur region is one of the factors causing dyslipidemia.

关 键 词：老年群体 维生素B12 血脂 

分 类 号：R589.2[医药卫生—内分泌] R446.1[医药卫生—内科学]