高压氧治疗对慢性意识障碍患者甲状腺激素水平及血脂的影响  

Effect of hyperbaric oxygen therapy on thyroid hormone levels and blood lipid in patients with chronic consciousness disorders

作　　者：谢晓娟 郭叶群 王佩奇 倪啸晓 Xie Xiaojuan;Guo Yequn;Wang Peiqi;Ni Xiaoxiao(Hyperbaric Oxygen Rehabilitation Department,PLA General Hospital of the Southern Theater Command,Guangzhou 510010,China;Nuclear Medicine Department,PLA General Hospital of the Southern Theater Command,Guangzhou 510010,China)

机构地区：[1]南部战区总医院高压氧康复科,广州510010 [2]南部战区总医院核医学科,广州510010

出　　处：《中华航海医学与高气压医学杂志》2024年第3期297-300,321,共5页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的:探讨高压氧治疗对慢性意识障碍患者甲状腺激素水平及血脂的影响。方法:选取2021年9月至2023年7月解放军南部战区总医院收治的20例慢性意识障碍且甲状腺激素水平下降的患者作为研究对象,根据是否行高压氧治疗分为对照组( n=10)和高压氧治疗组( n=10),比较2组患者治疗前后不同时间三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C),载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)水平。 结果:与治疗前比较,2组患者治疗后T3、T4、FT3、FT4及TSH水平差异无统计学意义;不同时间组间比较,2组患者T3、T4、FT3、FT4及TSH水平差异无统计学意义( P>0.05)。与治疗前比较,2组患者治疗后LDL-C、HDL-C及ApoA1水平差异无统计学意义( P>0.05),但高压氧治疗组患者TG、TC及ApoB水平明显降低,差异有统计学意义( P<0.05或 P<0.01);与对照组治疗3个月比较,高压氧治疗组患者TG、TC、LDL-C及ApoB水平明显降低,差异有统计学意义( P<0.05或 P<0.01)。 结论:高压氧治疗能调节慢性意识障碍患者的脂质代谢,降低动脉粥样硬化风险,保护心血管系统,但不能有效调节慢性意识障碍患者的甲状腺激素水平。ObjectiveTo explore the effect of hyperbaric oxygen therapy(HBOT)on thyroid hormone and blood lipid levels in patients with chronic consciousness disorders.MethodA total of 20 patients with chronic consciousness disorders and decreased thyroid hormone levels admitted to the PLA General Hospital of the Southern Theater Command from September 2021 to July 2023 were selected as the research subjects.According to whether HBOT was administered,they were divided into control group(n=10)and HBOT group(n=10).The levels of triiodothyronine(T3),thyroxine(T4),free triiodothyronine(FT3),free thyroxine(FT4),thyroid-stimulating hormone(TSH),triglycerides(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),apolipoprotein A1(ApoAI),and apolipoprotein B(ApoB)were compared between the two groups before and after treatment at different time points.ResultsCompared with their respective pre-treatment levels,both groups showed no statistically significant difference in the levels of T3,T4,FT3,FT4,and TSH after treatment.Additionally,there was no statistically significant difference in the levels of T3,T4,FT3,FT4,and TSH between the two groups at different time points(P>0.05).Compared with their respetive pre-treatment levels,both groups showed no statistically significant difference in the levels of LDL-C,HDL-C,and ApoAI after treatment(P>0.05).However,in the HBOT group,the levels of TG,TC,and ApoB significantly decreased(P<0.05 or P<0.01).When being compared with the control group after three months of treatment,the patients in the HBOT group showed significant decreases in TG,TC,LDL-C,and ApoB levels(P<0.05 or P<0.01).ConclusionHBOT can regulate lipid metabolism in patients with chronic consciousness disorders and reduce the risk of atherosclerosis,thus protecting the cardiovascular system.However,it cannot effectively regulate their thyroid hormone levels.

关 键 词：慢性意识障碍 高压氧治疗 甲状腺激素 血脂 

分 类 号：R459.6[医药卫生—治疗学]