中性粒细胞明胶酶相关脂质运载蛋白、抗磷脂酶A2受体抗体表达及尿视黄醇结合蛋白水平与慢性肾脏病的关系  

The Association of the Expression of Neutrophil Gelatinase Related Lipid Transporter,Anti Phospholipase A Receptor Antibody and Urine Retinol Binding Protein Levels with Chronic Kidney Disease

作　　者：陈玉莲 CHEN Yu-lian(Department of Nephrology,Jingjiang Peols's Hospital Affillated to Yangzhou Unirersity,Jingjiang Jiangsu 214500,China)

机构地区：[1]扬州大学附属靖江人民医院肾内科,江苏靖江214500

出　　处：《中华养生保健》2024年第16期39-42,共4页CHINESE HEALTH CARE

摘　　要：目的探讨与分析中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、抗磷脂酶A2受体抗体(PLA2R)表达及尿视黄醇结合蛋白(RBP)水平与慢性肾脏病的关系。方法选择2019年6月—2023年6月在扬州大学附属靖江人民医院诊治的120例慢性肾脏病患者作为研究对象,根据慢性肾脏病定义及经我国人群校正的EPI公式计算得出的估算肾小球滤过率水平将其分为观察组和对照组,将慢性肾脏病Ⅳ期到Ⅴ期的40例患者分为观察组,将Ⅰ期到Ⅲ期的80例患者分为对照组。检测所有患者的血清NGAL、PLA2R表达及RBP水平,检测肾功能常规指标并进行相关性分析。结果观察组的血清NGAL、PLA2R水平均高于对照组,差异有统计学意义(P<0.05)。观察组的RBP水平显著高于对照组,差异有统计学意义(P<0.05),观察组的血清尿素氮、血肌酐水平均显著高于对照组,差异有统计学意义(P<0.05)。在观察组中,Pearson分析显示血清尿素氮、血肌酐水平与NGAL、PLA2R、RBP水平均存在正向相关性,差异有统计学意义(P<0.05)。多因素logistic回归分析显示血清NGAL、PLA2R表达与RBP水平都为导致慢性肾脏病临床分期的重要因素,差异有统计学意义(P<0.05)。结论慢性肾脏病患者多伴随有血清NGAL、PLA2R表达及RBP水平升高,其与患者的常规肾功能指标存在相关性,也可影响慢性肾脏病的进展。Objective To investigate and analysis the relationship between the expression of neutrophil Gelatinase associated lipocalin(NGAL),anti Phospholipase A2 receptor(PLA2R),urinary Retinol binding protein(RBP)and Chronic kidney disease.Methods From June 2019 to June 2023,120 cases of patients with Chronic kidney disease diagnosed and treated in Jingjiang People's Hospital Affiliated to Yangzhou University were selected as the research subjects.According to the definition of chronic kidney disease and the EPI formula corrected by the Chinese population,jiang patients were divided into observation group and control group,there were 40 patients with Chronic kidney disease(stageⅣtoⅤ)judged(observation group)and 80 patients with stageⅠtoⅢ(control group)in the 120 cases.All the cases were to detect the expression of serum neutrophil Gelatinase related lipid carrier protein,anti Phospholipase A2 receptor antibody and urine Retinol binding protein,and were to detect routine indicators of renal function and carried out correlation analysis.Results The serum levels of neutrophil Gelatinase related lipid carrier protein and anti Phospholipase A2 receptor antibody in the obervation group were higher than those in the healthy group(P<0.05).The urine Retinol binding protein content,serum Blood urea nitrogen and creatinine of the obervation group was higher than that of the healthy group(P<0.05).In the obervation group,Pearson analysis showed that serum Blood urea nitrogen and serum creatinine levels were positively correlated with neutrophil Gelatinase related lipid transporter,anti Phospholipase A2 receptor antibody,and urinary Retinol binding protein(P<0.05).Multivariate logistic regression analysis showed that serum neutrophil Gelatinase related lipid transporter,anti Phospholipase A2 receptor antibody expression and urine Retinol binding protein level were important factors leaded to clinical stages of Chronic kidney disease(P<0.05).Conclusion Most patients with Chronic kidney disease are accompanied by the increased ex

关 键 词：慢性肾脏病 中性粒细胞明胶酶相关脂质运载蛋白 PLA2R 视黄醇结合蛋白 相关性 

分 类 号：R692.9[医药卫生—泌尿科学]