Proteomic analysis of urinary exosomes reveals ferroptosis-associated proteins are involved in diabetic nephropathy  

作　　者：Kaida Mu Yanping Yang Xiaofei An Jie Zhu Jing Zhang Yanfei Jiang Xiaorong Yang Jinan Zhang 

机构地区：[1]Department of Endocrinology and Metabolism,Shanghai University of Medicine&Health Sciences Affiliated Zhoupu Hospital,Shanghai 201318,China [2]Department of Endocrinology,Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210029,China

出　　处：《Genes & Diseases》2024年第5期6-8,共3页基因与疾病（英文）

基　　金：the Shanghai Municipal Health Commission health Industry clinical research special project(No.20214Y0353);Excellent young cultivation plan of Shanghai Pudong New Area Health System(No.PWRq2021-27);Top-100 Talent Cultivation Plan of Shanghai University of Medicine and Health Sciences(No.A3-0200-22-311007);The second round of medical discipline construction project of Pudong New Area-clinical characteristic discipline(No.PWYts2021-09).

摘　　要：Diabetic nephropathy(DN)is one of the major microvascular complications of diabetes mellitus and a major cause of end-stage renal disease(ESRD).The pathogenesis of DN is unknown,but it is closely related to disorders of glucolipid metabolism,abnormal hemodynamics,chronic inflammatory response,oxidative stress,and genetics.Once DN develops into ESRD,it is often more difficult to treat than ESRD caused by other kidney diseases.Therefore,a deeper knowledge of the pathophysiological mechanisms of DN and the discovery of candidate markers for early diagnosis are mandatory.Exosomes secreted by renal cells can regulate a series of pathophysiological processes such as translation and transcription by releasing miRNAs or proteins,thereby regulating the biological functions and phenotype of recipient kidney cells.It has been found that miRNA secreted by urinary exosomes in patients with DN is involved in the occurrence and development of DN and may become biological markers.1 However,studies on exosome proteins are relatively few and lack validation in humans.In the present study,we identified an altered pathway in urinary exosomes from DN patients for the first time.Notably,the altered ferroptosis-related proteins may represent novel candidate markers for early progression of disease and/or early treatment effects.

关 键 词：URINARY METABOLISM diagnosis 

分 类 号：R587.2[医药卫生—内分泌] R692[医药卫生—内科学]