精原干细胞自我更新及分化的调控机制研究进展  

Research advances in the regulatory mechanism of self-renewal and differentiation of spermatogonial stem cells

作　　者：潘瑜 李文鑫 张韫超 荆涛[1] PAN Yu;LI Wen-xin;ZHANG Yunchao;JING Tao(Department of Andrology,The Affiliated Hospital of Qingdao University,Qingdao 266000,China)

机构地区：[1]青岛大学附属医院男性科,山东青岛266000

出　　处：《青岛大学学报（医学版）》2024年第3期462-466,共5页Journal of Qingdao University(Medical Sciences)

基　　金：国家卫生健康委医药卫生科技发展中心项目(HDSL202001065)。

摘　　要：精原干细胞(SSC)是睾丸中最原始的生殖细胞,通过自我更新和连续分化最终成为成熟的精子,SSC对维持高效的精子发生起着至关重要的作用,与生精微环境(niche)之间复杂的分子和细胞相互作用构成了精子发生的基础。以往认为niche主要由睾丸支持细胞构成,而新近研究表明,睾丸内多种细胞、分子信号通路均参与调控SSC的自我更新及分化。本文就睾丸生精微环境调控SSC自我更新及分化的研究进展进行综述。Spermatogonial stem cells(SSC)arethe most primitive germ cells in the testis and develop into mature sperms through self-renewal and continuous differentiation.SSC play an important role in maintaining efficient spermatogenesis,and the complex molecular and cellular interactions between SSC and microenvironment(also called niche)form the basis of spermatogenesis.Previous studies believed that the niche was mainly composed of Sertoli cells,but recent studies have shown that various types of cells and molecular signaling pathways in the testis are involved in the regulation of the self-renewal and differentiation of SSC.This article reviews the research advances in the microenvironment for spermatogenesis in the testis in regulating the self-renewal and differentiation of SSC.

关 键 词：成体生殖干细胞 细胞自我更新 细胞分化 精子发生 综述 

分 类 号：R321.1[医药卫生—人体解剖和组织胚胎学]