多组学技术阐明创伤后脓毒症发病机制的作用研究进展  

Role of multi‑omics technology in elucidating the pathogenesis of post‑traumatic sepsis:a review

作　　者：郑鸿生 赵子刚[1] 刘浩儒 唐婉琦 张晨 梁华平 杨霞 Zheng Hongsheng;Zhao Zigang;Liu Haoru;Tang Wanqi;Zhang Chen;Liang Huaping;Yang Xia(Department of Emergency,Chonggang General Hospital,Chongqing 400081,China;Research Office of War Wound Infection and Special Drug,Army Medical Center,Army Medical University,Chongqing 400042,China)

机构地区：[1]重庆重钢总医院急诊科,重庆400081 [2]陆军军医大学陆军特色医学中心战伤感染与特需药品研究室,重庆400042

出　　处：《中华创伤杂志》2024年第7期660-666,共7页Chinese Journal of Trauma

基　　金：重庆市科卫联合医学科研面上项目(2020MSXM059)。

摘　　要：脓毒症是一种机体对感染反应失调的全身炎症反应综合征,具有持续感染、过度炎症和免疫抑制等特点,通常会导致器官功能障碍进而危及生命,是创伤后常见的并发症。由于创伤后脓毒症的病因、病程进展、预后等因素错综复杂,目前其发病机制尚不明确。多组学技术可将两个及以上的单一组学联合起来进行全面综合分析的技术,能够从多角度、多方面揭示疾病相关分子间相互作用网络,对创伤后脓毒症发病机制解析具有重大意义。为此,笔者从基因组学、转录组学、蛋白质组学、代谢组学、单细胞转录组学及多组学技术联合等方面就多组学技术对阐明创伤后脓毒症发病机制作用的研究进展进行综述,为创伤后脓毒症的研究方法提供参考。Sepsis is a syndrome of systemic inflammatory response in which the body′s response to infection is dysregulated,and is characterized by persistent infection,excessive inflammation and immunosuppression,etc.It often leads to organ dysfunction and can be life threatening,and also a common complication after trauma.The pathogenesis of post‑traumatic sepsis is still unclear at present due to the complexity of its etiology,progression and prognosis.Multi‑omics technology is a method to combine two or more single omics for comprehensive analysis,which can reveal the interaction network among the disease‑associated molecules from multiple perspectives and aspects and is of great significance for the analysis of the pathogenesis of post‑traumatic sepsis.To this end,the authors reviewed the research progress on the role of multi‑omics technology in elucidating the pathogenesis of post‑traumatic sepsis from the perspectives of genomics,transcriptomics,proteomics,metabolomics,single‑cell transcriptomics and combination of multi‑omics technologies,etc so as to provide a reference for the researches on post‑traumatic sepsis.

关 键 词：创伤和损伤 脓毒症 基因组学 蛋白质组学 发病机制 

分 类 号：R459.7[医药卫生—急诊医学]