基于阴阳理论探讨自噬在卵巢癌中的作用  

Role of Autophagy in Ovarian Cancer Based on Yin and Yang Theory

作　　者：彭成 郭滢[2] 于洋[2] 刘芳媛 韩凤娟[2] PENG Cheng;GUO Ying;YU Yang;LIU Fangyuan;HAN Fengjuan(Heilongjiang University of Chinese Medicine,Harbin 150040,China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]黑龙江中医药大学附属第一医院,哈尔滨150040

出　　处：《中国实验方剂学杂志》2024年第16期185-192,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(82074484,82274566)。

摘　　要：卵巢癌作为妇科恶性肿瘤之一,早期症状不典型,转移复发率高,是严重威胁女性健康的重要杀手。中医认为,阴阳平衡指导机体功能与物质的动态转换,实现气血津液的正常输布,协调肌肉官窍的充盛强壮;而阴阳失衡,气血积聚络于胞宫发为卵巢癌。随着现代研究的进展发现,自噬作为机体内代谢与产能的变化过程,亦具有阴阳的动态属性,自噬抑制“阳衰阴盛”促进卵巢癌的形成、自噬激活“阳生阴长”推动卵巢癌的发展、瘤体机体“阴阳自噬紊乱”卵巢癌复发耐药,提示卵巢癌的发生发展与阴阳二者的病理状态高度契合。故该文以中医阴阳理论对卵巢癌及自噬相关机制阐释为基础,以卵巢癌不同阶段的主体矛盾为出发点,提出各阶段的防治原则:初以“益火源”激活自噬“消阴翳”,进以“攻毒结”抑制自噬“通阳滞”,末以“平阴阳”控制自噬“缓病势”。强调在动态调度阴阳、调和自噬、正邪同治、扶祛兼顾为定法的基础上,随变治之,依症加减。提出中西医结合治疗卵巢癌的临床方法及理论依据,以期为卵巢癌的防治拓展新思路、促进中医理论的现代化诊疗进程。As one of the malignant gynecological malignant tumors,ovarian cancer has atypical early symptoms and a high rate of metastasis and recurrence,making it a significant threat to women's health.Traditional Chinese medicine(TCM)believes that the balance of Yin and Yang guides the dynamic transformation of functions and substances in the body,achieving normal distribution of Qi,blood,and body fluids,and coordinating the strength and vitality of muscles and organs.Conversely,the imbalance of Yin and Yang,with the accumulation of Qi and blood in the uterus,can lead to ovarian cancer.With the progress on modern research,it has been found that autophagy,a process involving metabolic and energy changes within the body,also exhibits dynamic attributes of Yin and Yang.Inhibition of autophagy corresponds to"Yang decline and Yin excess",promoting the formation of ovarian cancer,while activation of autophagy corresponds to"Yang growth and Yin flourishing",driving the development of ovarian cancer.Tumor body autophagy imbalance,characterized by"Yin-Yang autophagy disorder",is associated with ovarian cancer recurrence and drug resistance,suggesting a high correlation between the pathogenesis of ovarian cancer and the pathological states of Yin and Yang.Therefore,based on the explanation of the related mechanisms of ovarian cancer and autophagy from Yin and Yang theory in TCM,this paper took the main contradictions of different stages of ovarian cancer as the starting point,and put forward the prevention and treatment principles for each stage:initially"nourishing the source of fire"to activate autophagy and"eliminate yin obstruction",then"attacking the toxic knot"to inhibit autophagy and"unblock yang stagnation",and finally"balancing Yin and Yang"to control autophagy and"slow the disease progression".It emphasized dynamically regulating Yin and Yang,harmonizing autophagy,treating both healthy and pathogenic Qi,and adapting reinforcing and expelling therapies,further preforming treatment along with variations and syndromes.The ar

关 键 词：阴阳理论 卵巢癌 自噬 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学] R289R287R22R2-031R33R24