5%酞丁胺霜剂联合艾拉光动力对尖锐湿疣治疗效果及病毒载量的影响  

The Therapeutic Effect and Viral Load of 5% Phthalamine Cream Combined with Ella Photodynamic Therapy on Genital Warts

作　　者：马雪姣 MA Xue-Jiao(Department of Dermatology and Venereal Diseases,Fuxin Mine General Hospital,Liaojian Group,Fuxin 123000,China)

机构地区：[1]辽健集团阜新矿总医院皮肤与性病科,辽宁阜新123000

出　　处：《中国药物经济学》2024年第6期85-87,96,共4页China Journal of Pharmaceutical Economics

摘　　要：目的探讨5%酞丁胺霜剂联合艾拉光动力对尖锐湿疣治疗效果及病毒载量的影响。方法选取2019年1月至2022年1月辽健集团阜新矿总医院收治的108例尖锐湿疣患者作为研究对象,采用随机数字表法分为对照组与观察组,每组54例。对照组予以单纯艾拉光动力治疗,观察组采用5%酞丁胺霜剂联合艾拉光动力治疗。比较两组患者临床疗效,治疗前后人乳头瘤病毒(HPV)载量变化以及复发率,治疗前后T淋巴细胞亚群水平变化以及不良反应发生率。结果观察组治疗有效率明显高于对照组(P<0.05);两组治疗前HPV载量比较差异无统计学意义(P>0.05);治疗后两组HPV载量降低,且观察组低于对照组,差异有统计学意义(P<0.05);观察组复发率低于对照组(P<0.05);治疗前两组CD4^(+)、CD3^(+)、CD4^(+)/CD8^(+)水平比较差异无统计学意义(P>0.05);治疗后两组CD4^(+)、CD3^(+)、CD4^(+)/CD8^(+)水平升高,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论5%酞丁胺霜剂联合艾拉光动力可提升尖锐湿疣的临床疗效,且能够有效降低HPV载量,减少复发,改善患者免疫功能,安全性较高。Objective To explore the therapeutic effect and viral load of 5% Phthalbutamine cream combined with Ella photodynamic therapy on genital warts.Methods A total of 108 patients with condyloma acuminatum treated in Fuxin Mine General Hospital of Liaojian Group from January 2019 to January 2022 were selected as the study objects,and were divided into control group and observation group by random number table method,with 54 cases in each group.The control group was treated with pure Ella photodynamic therapy,and the observation group was treated with 5% thalbutamine cream combined with Ella photodynamic therapy.The clinical efficacy,changes in HPV load before and after treatment and recurrence rate,changes in T lymphocyte subsets before and after treatment,and the incidence of adverse reactions were compared between the two groups.Results The effective rate of the observation group was significantly higher than that of the control group(P<0.05).There was no significant difference in HPV load between the two groups before treatment(P>0.05).After treatment,the HPV load in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The recurrence rate of observation group was lower than that of control group(P<0.05).There was no significant difference in the levels of CD4^(+),CD3^(+)and CD4^(+)/CD8^(+)between the two groups before treatment(P>0.05).After treatment,the levels of CD4^(+),CD3^(+)and CD4^(+)/CD8^(+)were increased in both groups,and the observation group was higher than the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion 5% phthalamine cream combined with Ella photodynamic can improve the clinical efficacy of condyloma acuminatum,and can effectively reduce HPV load,reduce recurrence,improve the immune function of patients,and high safety.

关 键 词：5%酞丁胺霜剂 艾拉光动力 尖锐湿疣 病毒载量 复发率 

分 类 号：R759.3[医药卫生—皮肤病学与性病学] R986[医药卫生—临床医学]