TORCH筛查在育龄男女健康检查中的临床应用价值  

Clinical application value of TORCH screening in health examination of men and women of childbearing age

作　　者：李静[1,2] 王莹 毕亮亮[1,2] 梅晓峰[1,2] 李金刚[1,2] 白梦刻 杨晓青[1,2] 张霞[1,2] LI Jing;WANG Ying;BI Liang-liang;MEI Xiao feng;LIJin-gang;BAI Meng ke;YANG Xiao-qing;ZHANG Xia(Pediatric Hospital of the First Affiliated Hospital of Henan University of Chinese,Zhengzhou 450000,China;College of Pediatrics,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学第一附属医院儿科医院,郑州450000 [2]河南中医药大学儿科医学院,郑州450000

出　　处：《医药论坛杂志》2024年第12期1248-1251,1256,共5页Journal of Medical Forum

基　　金：河南省自然科学基金项目面上项目(222300420488);河南省科技研发计划联合基金项目(222301420078);2022年度河南省中青年学科带头人培养项目[豫卫人(2022)26号]。

摘　　要：目的了解本地区育龄男女TORCH的感染状况,分析并探讨TORCH筛查在育龄男女健康检查中的临床应用价值,以期为优生优育提供更好的临床指导。方法回顾性收集2020年4月至2023年1月来河南中医药大学第一附属医院儿科实验室接受TORCH筛查的育龄男女2272例。采用直接化学发光法定量检测TORCH各病原体的IgM、IgG抗体。采用SPSS 25.0分析数据。结果在2272例育龄男女中TORCH各病原体IgM抗体的阳性率由高到低为HSV-1-IgM(0.40%)、CMV-IgM(0.31%)、TOX-IgM(0.22%)、HSV-2-IgM(0.22%)、RV-IgM(0.18%);IgG抗体的阳性率由高到低为CMV-IgG(95.07%)、HSV-1-IgG(90.10%)、RV-IgG(80.59%)、HSV-2-IgG(7.22%)、TOX-IgG(0.66%);IgM+IgG抗体双阳性率由高到低为HSV-1-IgM+IgG双阳性(0.40%)、CMV-IgM+IgG双阳性(0.31%)、RV-IgM+IgG双阳性(0.18%)。不同性别间育龄男性HSV-1-IgG、HSV-2-IgG的阳性率低于女性,差异有统计学意义(P<0.05)。不同年龄组高龄组RV-IgG的阳性率低于低龄组,高龄组HSV-2-IgG的阳性率高于低龄组,差异有统计学意义(P<0.05)。结论由于预防新型冠状病毒疫情所采取的积极有效的防护措施,使得TORCH各病原体以RV为主的近期感染率明显降低。在育龄男女的健康检查中扩大TORCH的筛查范围和提高筛查的频率,并依据筛查结果采取相应的防范措施,以避免不良妊娠的发生及降低出生缺陷率。Objective To investigate the prevalence of TORCH infections among reproductive-aged men and women in the local area,and to analyze and explore the clinical application value of TORCH screening in reproductive-aged men and women's health examination,in order to provide better clinical guidance for eugenics and postnatal care.Methods A total of 2272 reproductive-aged men and women who underwent TORCH screening in pediatric laboratory of the First Affiliated Hospital of Henan University of Chinese Medicine from April 2020 to January 2023 were collected retrospectively.The IgM and IgG antibodies of TORCH pathogens were quantitatively detected by direct chemiluminescence method.SPSS 25.0 was used to analyze the data.Results Among the 2272 reproductive-aged men and women,the positivity rates of TORCH IgM antibodies from high to low were HSV-Ⅰ-IgM(0.40%),CMV-IgM(0.31%),TOX-IgM(0.22%),HSV-Ⅱ-IgM(0.22%),and RV-IgM(0.18%);the positive rates of IgG antibodies from high to low were CMV-IgG(95.07%),HSV-Ⅰ-IgG(90.10%),RV-IgG(80.59%),HSV-Ⅱ-IgG(7.22%),and TOX-IgG(0.66%);the double positive rates of IgM+IgG from high to low were HSV-Ⅰ-IgM+IgG double-positive(0.40%),CMV-IgM+IgG double-positive(0.31%),and RV-IgM+IgG double-positive(0.18%).The positive rates of HSV-Ⅰ-IgG and HSV-Ⅱ-IgG among reproductive-aged women were higher than those among reproductive-aged men,and the difference was statistically significant(P<0.05).According to age grouping,the RV-IgG positive rate in the older age group was lower than that in the younger age group,while the HSV-Ⅱ-IgG positive rate was higher than that in the younger age group,and the difference was statistically significant(P<0.05).Conclusion Due to the active and effective protective measures taken to prevent the epidemic situation in novel coronavirus,the recent infection rate of RV-based pathogens in TORCH has been significantly reduced.Expand the screening scope and frequency of TORCH in the health examination of reproductive-aged men and women,and take corresponding preventi

关 键 词：TORCH 弓形虫 风疹病毒 巨细胞病毒 单纯疱疹病毒 

分 类 号：R446.6[医药卫生—诊断学]