LDL、HDL不同亚型与老年T2DM并冠心病患者AIP指数、syntax积分的关系  

Relationship of different subtypes of LDL and HDL with AIP index and syntax score in elderly patients with T2DM and coronary heart disease

作　　者：王章 邬真力 孟军军 李辰浩 WANG Zhang;WU Zheni;MENG Junjun;LI Chenhao(Department of Geriatrics Center,Inner Mongolia Autonomous Region People’s Hospital,Hohhot,Inner Mongolia,China,010017;Department of Statistics Quality Management,Inner Mongolia Autonomous Region People’s Hospital,Hohhot,Inner Mongolia,China,010017)

机构地区：[1]内蒙古自治区人民医院老年医学中心,内蒙古呼和浩特010017 [2]内蒙古自治区人民医院质量管理处统计室,内蒙古呼和浩特010017

出　　处：《分子诊断与治疗杂志》2024年第7期1220-1224,共5页Journal of Molecular Diagnostics and Therapy

基　　金：内蒙古自治区自然科学基金项目(2022MS08098)。

摘　　要：目的 探究低密度脂蛋白(LDL)、高密度脂蛋白(HDL)不同亚型与老年2型糖尿病(T2DM)并冠心病患者血浆致动脉粥样硬化指数(AIP)、syntax积分的关系。方法 选取2019年1月至2022年10月内蒙古自治区人民医院收治的158例老年T2DM并冠心病患者为研究组,另选50例老年单纯冠心病患者为对照组,均行冠状动脉造影检查,并检测血清LDL、HDL不同亚型水平及AIP指数,研究组按syntax积分再分为低分组(n=68)、中分组(n=54)及高分组(n=36),分析LDL、HDL不同亚型与老年T2DM并冠心病患者AIP指数、syntax积分的关系。结果 研究组大而轻LDL、中密度LDL、小而密LDL、HDL3、AIP、syntax积分均高于对照组,HDL2低于对照组,差异有统计学意义(P<0.05)。高分组患者BMI、TG水平高于低分组、中分组,高血压、吸烟、饮酒比例低于低分组、中分组,差异均有统计学意义(P<0.05);高分组患者中密度LDL、小而密LDL、HDL3、AIP、syntax积分均明显高于低分组、中分组,HDL2明显低于低分组、中分组,差异均有统计学意义(P<0.05)。Pearson分析显示,老年T2DM并冠心病患者的中密度LDL、小而密LDL、HDL3水平与AIP、syntax积分均呈正相关(P<0.05),HDL2与AIP、syntax积分均呈负相关(P<0.05)。多因素Logistic回归分析示,体质量指数(BMI)、甘油三酯(TG)、中密度LDL、小而密LDL、HDL2、HDL3均是老年T2DM并冠心病患者syntax积分>32分的独立影响因素(P<0.05)。结论 LDL、HDL不同亚型水平变化与老年T2DM并冠心病患者AIP指数、syntax积分均明显相关,T2DM并冠心病患者不同亚型的LDL水平越高、HDL2水平越低,则T2DM并冠心病动脉硬化程度越严重。Objective To explore the relationship between different subtypes of low-density lipo-protein(LDL)and high-density lipoprotein(HDL)and atherogenic index of plasma(AIP),syntax score in elderly patients with type 2 diabetes mellitus(T2DM)complicated with coronary heart disease.Methods 158 elderly patients with T2DM and coronary heart disease were selected as the study group,and 50 elderly pa-tients with simple coronary heart disease were enrolled as the control group.All patients underwent coronary angiography.The levels of different subtypes of serum LDL and HDL and AIP index were detected.Based on the syntax score,the patients in the study group were divided into three groups:low score group(n=68),middle score group(n=54)and high score group(n=36).The relationship between different subtypes of LDL and HDL with the AIP index and syntax score in elderly T2DM patients with coronary heart disease was ana-lyzed.Results The large and light LDL,medium-density LDL,small and dense LDL,HDL3,AIP and syn-tax score in the study group were higher than those in the control group while HDL2 was lower than that in the control group(P<0.05).BMI and TG in the high score group were higher while the proportions of hyperten-sion,smoking and drinking were lower than those in the low score group and middle score group(P<0.05).The medium-density LDL,small and dense LDL,HDL3,AIP and syntax score in the high score group were significantly higher while HDL2 was significantly lower compared to the low score group and middle score group(P<0.05).Pearson correlation analysis revealed that medium-density LDL,small and dense LDL and HDL3 were positively correlated with AIP and syntax score(P<0.05),and HDL2 was negatively correlated with AIP and syntax score(P<0.05).Multivariate logistic regression analysis showed that body mass index(BMI),triglyceride(TG),medium-density LDL,small and dense LDL,HDL2 and HDL3 were independent influencing factors of syntax score>32 points in elderly T2DM patients with coronary heart disease(P<0.05).Conclusion The cha

关 键 词：2型糖尿病 冠心病 低密度脂蛋白 高密度脂蛋白 血浆致动脉粥样硬化指数 

分 类 号：R541.4[医药卫生—心血管疾病] R587.1[医药卫生—内科学]