调Q1064 nm激光辅助治疗对黄褐斑患者皮损情况及LH、VEGF及COX-2水平的影响  

Effects of Q⁃tuned 1064 nm laser⁃assisted therapy on skin lesions and levels of LH,VEGF and COX⁃2 in patients with melasma

作　　者：韩丽 段文娟 HAN Li;DUAN Wenjuan(Department of Dermatology and Cosmetology,Jieshou Traditional Chinese Medicine Hospital,Jieshou,Anhui,China,236500)

机构地区：[1]界首市中医院皮肤美容科,安徽界首236500

出　　处：《分子诊断与治疗杂志》2024年第7期1294-1297,1302,共5页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省教育厅高校科学研究项目(KJ2020A0859)。

摘　　要：目的 探讨调Q1064 nm激光辅助治疗对黄褐斑患者皮损情况及促黄体生成素(LH)、血管内皮生长因子(VEGF)、环氧化酶-2(COX-2)水平的影响。方法 回顾性选取2021年7月至2023年6月于界首市中医院皮肤美容科门诊进行治疗的黄褐斑患者126例,按照纳入排除标准,最终纳入114例黄褐斑患者作为研究对象进行回顾性分析。根据治疗方式分为对照组(n=55,常规药物治疗)和观察组(n=59,常规药物治疗+调Q1064 nm激光)。比较两组患者皮损情况、LH、VEGF以及COX-2水平、临床疗效和并发症发生率。结果 治疗后,观察组MASI总分低于对照组,差异有统计学意义(P<0.05);观察组皮损面积评分、皮损颜色评分均低于对照组,差异有统计学意义(P<0.05);观察组LH、COX-2水平比对照组低,VEGF水平比对照组高,差异有统计学意义(P<0.05);观察组患者临床疗效总有效(91.52%)率高于对照组(76.36%),差异有统计学意义(P<0.05);两组并发症比较差异无统计学意义(P>0.05)。结论调Q1064 nm激光辅助治疗可以有效降低黄褐斑患者LH、COX-2水平,提高VEGF水平,进而减轻皮损部位氧化应激损伤,显著改善患者皮损情况,安全性较高。Objective To investigate the effects of Q-tuned 1064 nm laser-assisted therapy on skin lesions and levels of luteinising hormone(LH),vascular endothelial growth factor(VEGF)and cyclo-oxygenase-2(COX-2)in patients with melasma.Methods 126 patients with chloasma who were treated in the outpatient clinic of the Department of Dermatology and Cosmetology at Jieshou Hospital of Traditional Chi-nese Medicine from July 2021 to June 2023 were selected.114 patients with chloasma met the clusion and ex-culusion criteria and were included in the restrospective analysis.The patients were divided into two groups based on treatment methods:the control group(n=55,receiving conventional drug therapy)and the observa-tion group(n=59,receiving conventional drug therapy+Q1064 nm laser modulation).Skin lesions,levels of LH,VEGF and COX-2,clinical efficacy,and incidence of complications were compared between the two groups.Results After treatment,the total MASI score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The lesion area score and lesion color score of the observation group were also lower than those of the control group,and the difference was statisti-cally significant(P<0.05).Additionally,the LH and COX-2 levels of the observation group were lower than those of the control group,while the VEGF level was higher.These differences were statistically significant(P<0.05).The total effective rate of clinical efficacy in the observation group(91.52%)was higher than that in the control group(76.36%),and the difference was statistically significant(P<0.05).There was no signifi-cant difference in complications between the two groups(P>0.05).Conclusion Q-tuned nm laser assisted therapy can effectively reduce the levels of LH and COX-2 in patients with melasma,increase the levels of VEGF,reduce oxidative stress damage in the skin lesions,and significantly improve the skin lesions in pa-tients with high safety.

关 键 词：调Q1064nm激光 黄褐斑 皮损 LH VEGF COX-2 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]