特发性扩张型心肌病患者miR-34a-5p、miR-17-5p表达水平及其与心衰的关系  

Expression Levels of miR⁃34a⁃5p and miR⁃17⁃5p in Patients with Idiopathic Dilated Cardiomyopathy and Their Relationship with Heart Failure

作　　者：刘丹丹 孔洪[2] 邱清艳[3] 樊毅虎 LIU Dandan;KONG Hong;QIU Qingyan;FAN Yihu(Department of Cardiovascular,Youxian District Traditional Chinese Medicine Hospital,Mianyang,Sichuan,China,621000;Heart Failure Center,Sichuan People’s Hospital,Chengdu,Sichuan,China,610000;Department of Cardiovascular,Mianyang Central Hospital,Mianyang,Sichuan,China,621000;Department of Cardiovascular,Xi'an Fengcheng Hospital,Xi'an,Shaanxi,China,710021)

机构地区：[1]绵阳市游仙区中医医院心血管内科,四川绵阳621000 [2]四川省人民医院心衰中心,四川成都610000 [3]绵阳市中心医院心血管内科,四川绵阳621000 [4]西安凤城医院心血管内科,陕西西安710021

出　　处：《分子诊断与治疗杂志》2024年第7期1345-1349,共5页Journal of Molecular Diagnostics and Therapy

基　　金：四川省科技计划项目(2023ZYZFSY15)。

摘　　要：目的 探讨特发性扩张型心肌病(IDCM)患者miR-34a-5p、miR-17-5p表达水平及其与心衰的关系。方法 选取2019年1月至2023年1月绵阳市游仙区中医医院和四川省人民医院联合收治的IDCM患者136例(IDCM组),根据IDCM患者是否继发心力衰竭分为心衰组40例和非心衰组96例。选取同期68名无心脏病的健康志愿者设为对照组。比较IDCM组与对照组、心衰组与非心衰组的血清miR-34a-5p、miR-17-5p表达水平、N末端B型利钠肽(NT-proBNP)、超敏肌钙蛋白T(hs-TnT)、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)。分析血清miR-34a-5p、miR-17-5p表达水平与心功能指标的相关性。采用ROC曲线分析miR-34a-5p、miR-17-5p对IDCM继发心衰的预测价值。结果 IDCM组的血清miR-34a-5p、miR-17-5p表达水平高于对照组,差异有统计学意义(P<0.05)。IDCM组的血清NT-proBNP、hs-TnT水平高于对照组,LVEF低于对照组,LVEDD高于对照组,差异有统计学意义(P<0.05)。心衰组的血清miR-34a-5p、miR-17-5p表达水平高于非心衰组,差异有统计学意义(P<0.05)。心衰组的血清NT-proBNP水平高于非心衰组,LVEF低于非心衰组,LVEDD高于非心衰组,差异有统计学意义(P<0.05)。血清miR-34a-5p、miR-17-5p表达水平与血清NT-proBNP水平呈正相关(r=0.498,r=0.306,P<0.001)。血清miR-34a-5p联合miR-17-5p预测IDCM继发心衰的灵敏度为0.875,特异度为0.802。结论 IDCM患者存在miR-34a-5p、miR-17-5p表达水平上调情况,且miR-34a-5p、miR-17-5p表达水平与心衰具有关联,对预测心衰有一定价值。Objective To explore the expression levels of miR-34a-5p and miR-17-5p and their re-lationship with heart failure in patients with idiopathic dilated cardiomyopathy(IDCM).Methods A total of 136 patients with IDCM were enrolled in the IDCM group between January 2019 and January 2023 in Youxian District Traditional Chinese Medicine Hospital and Sichuan Provincial People’s Hospital,Mianyang.Based on presence or absence of heart failure,they were divided into a heart failure group(40 cases)and a non-failure group(96 cases).A total of 68 healthy volunteers without heart disease during the same period were enrolled as control group.The expression levels of miR-34a-5p and miR-17-5p,N-terminal pro brain natriuretic peptide(NT-proBNP),hypersensitive troponin T(hs-TnT),left ventricular ejection fraction(LVEF)and left ven-tricular end-diastolic inner diameter(LVEDD)were compared between the IDCM group and the control group,and between the heart failure group and the non-failure group.The correlation between serum miR-34a-5p,miR-17-5p and cardiac function indexes was also analyzed.The predictive value of miR-34a-5p and miR-17-5p for heart failure was analyzed using ROC curves.Results The levels of serum miR-34a-5p and miR-17-5p in the IDCM group were higher than those in the control group(P<0.05),the levels of serum NT-proBNP and hs-TnT were higher than those in the control group(P<0.05).The LVEF was lower in the IDCM group than in the control group(P<0.05),and the LVEDD was higher than that in the control group(P<0.05).The ex-pression levels of serum miR-34a-5p and miR-17-5p in the heart failure group were higher than those in the non-failure group(P<0.05).Similarly,the level of serum NT-proBNP was higher than that in the non-failure group(P<0.05).The LVEF was lower in the heart failure group than in the non-failure group(P<0.05),and the LVEDD was higher than that in the non-failure group(P<0.05).The expression levels of serum miR-34a-5p and miR-17-5p were positively correlated with the level of serum NT-proBNP(r=0.498,r=

关 键 词：特发性扩张型心肌病 心力衰竭 miR-34a-5p miR-17-5p 

分 类 号：R542.2[医药卫生—心血管疾病] R541.6[医药卫生—内科学]