蒲参胶囊联合二甲双胍治疗2型糖尿病合并颈部动脉粥样硬化的临床疗效  

Clinical Effect of Pushen Capsule Combined with Metformin in the Treatment of Type 2 Diabetes Mellitus with Cervical Atherosclerosis

作　　者：刘丹 薛敏[1] 曹丹 恽瑞元[1] LIU Dan;XUE Min;CAO Dan;YUN Ruiyuan(Department of Endocrinology,Jingjiang People's Hospital,Taizhou 214500,Jiangsu,China)

机构地区：[1]靖江市人民医院内分泌科,江苏泰州214500

出　　处：《世界复合医学》2024年第4期17-20,共4页World Journal of Complex Medicine

摘　　要：目的 研究蒲参胶囊和二甲双胍联合应用于2型糖尿病并发颈部动脉粥样硬化患者的价值。方法 选取2022年1月—2023年10月靖江市人民医院收治的86例2型糖尿病合并颈动脉粥样硬化患者为研究对象,经随机数表法分为两组,每组43例。对照组应用二甲双胍和阿司匹林肠溶片治疗,观察组在对照组基础上加用蒲参胶囊治疗。比较两组糖脂代谢指标、血清炎症反应指标及动脉粥样硬化指标水平变化情况。结果 治疗后,观察组患者各项糖脂代谢指标、血清炎症反应指标均显著优于对照组,差异有统计学意义(P均<0.05);观察组颈动脉中层厚度为(0.86±0.27)mm,斑块面积(14.97±1.29)mm^(2),斑块数量为(1.07±0.16)个,均优于对照组,差异有统计学意义(t=3.874、8.112、19.767,P均<0.05)。结论 2型糖尿病合并颈部动脉粥样硬化患者应用蒲参胶囊联合二甲双胍治疗的疗效理想。Objective To study the value of Pushen capsule combined with metformin in patients with type 2 diabetes mellitus complicated with cervical atherosclerosis.Methods A total of 86 patients with type 2 diabetes mellitus complicated with carotid atherosclerosis admitted to Jingjiang People's Hospital from January 2022to October 2023 were selected as the research objects and divided into two groups by random number table method,with 43 cases in each group.The control group was treated with metformin and aspirin enteric-coated tablets,and the observation group was treated with Pusshen capsule on the basis of the control group.The changes of glucose and lipid metabolism indexes,serum inflammatory response indexes and atherosclerosis indexes were compared between the two groups.Results After treatment,the indexes of glucose and lipid metabolism and serum inflammatory response in observation group were significantly better than those in control group,and the differences were statistically significant(all P<0.05).Carotid media thickness(0.86±0.27) mm,plaque area(14.97±1.29) mm^(2),and plaque number(1.07±0.16) in observation group were better than those in control group,and the differences were statistically significant(t=3.874,8.112,19.767,all P<0.05).Conclusion The treatment effect of Pushen capsule combined with metformin in patients with type 2 diabetes mellitus and neck atherosclerosis is ideal.

关 键 词：二甲双胍 蒲参胶囊 2型糖尿病 颈部动脉粥样硬化 

分 类 号：R587[医药卫生—内分泌]