探讨麝香保心丸联合阿托伐他汀治疗冠心病的效果及对患者心功能的影响  

Effect of Shexiang Baoxin Pills Combined with Atorvastatin on Coronary Heart Disease and Its Influence on Cardiac Function

作　　者：朱呈娟 戴桂松 刘洪伟[2] ZHU Chengjuan;DAI Guisong;LIU Hongwei(Department of Pharmacy,Xinghua Hospital of Traditional Chinese Medicine,Xinghua 225700,Jiangsu,China;Department of Cardiology,Xinghua Hospital of Traditional Chinese Medicine,Xinghua 225700,Jiangsu,China)

机构地区：[1]江苏省兴化市中医院药剂科,江苏兴化225700 [2]江苏省兴化市中医院心内科,江苏兴化225700

出　　处：《世界复合医学》2024年第4期54-57,共4页World Journal of Complex Medicine

摘　　要：目的 研究麝香保心丸联合阿托伐他汀治疗冠状动脉粥样硬化性心脏病(简称冠心病)的效果及对患者心功能的影响。方法 选取2021年5月—2023年5月江苏省兴化市中医院收治的96例冠心病患者为研究对象,依照随机数表法分为对照组、观察组,每组48例。对照组采用阿托伐他汀治疗,观察组采用麝香保心丸联合阿托伐他汀治疗。比较两组治疗效果、心功能、不良反应发生率。结果 观察组治疗总有效率(97.92%)高于对照组(79.17%),差异有统计学意义(χ^(2)=8.316,P<0.05)。治疗前,两组心功能指标比较,差异无统计学意义(P均>0.05);治疗后,两组心功能均改善,且观察组左室舒张末期内径、左室收缩末期内径小于对照组,左室射血分数高于对照组,差异有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 麝香保心丸+阿托伐他汀治疗冠心病有更好的效果,能改善心功能,且安全性高。Objective To study the effect of Shexiang Baoxin Pills combined with atorvastatin on coronary heart disease and its influence on cardiac function.Methods Ninety-six patients with coronary heart disease admitted to Xinghua Hospital of Traditional Chinese Medicine in Jiangsu Province from May 2021 to May 2023were selected as the study objects,and they were divided into control group and observation group according to random number table method,with 48 cases in each group.The control group was treated with atorvastatin,and the observation group was treated with Shexiang Baoxin pills combined with atorvastatin.The therapeutic effect,cardiac function and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group(97.92%) was higher than that of the control group(79.17%),and the difference was statistically significant(χ^(2)=8.316,P<0.05).Before treatment,there were no significant differences in cardiac function between the two groups(all P>0.05).After treatment,cardiac function improved in both groups,and the left ventricular end-diastolic dimension,left ventricular end-systolic diameter in the observation group were lower than those of control group,and left ventricular ejection fraction was higher than that of control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Shexiang Baoxin Pills combined with atorvastatin has better effect in the treatment of coronary heart disease,can improve cardiac function more,and has high safety.

关 键 词：冠心病 麝香保心丸 阿托伐他汀 心功能 不良反应 

分 类 号：R9[医药卫生—药学]