不同激素治疗方案对女性围绝经期异常子宫出血的临床疗效分析  

Clinical Effect of Different Hormone Therapy Regimens on Abnormal Uterine Bleeding in Perimenopausal Women

作　　者：闫猛 刘雯 YAN Meng;LIU Wen(Department of Obstetrics and Gynecology,Shenxian Maternal and Child Health Hospital,Liaocheng 252000,Shandong,China;Shandong University Qilu Hospital,Jinan 250000,Shandong,China)

机构地区：[1]莘县妇幼保健院妇产科,山东聊城252000 [2]山东大学齐鲁医院,山东济南250000

出　　处：《系统医学》2024年第12期150-153,共4页Systems Medicine

摘　　要：目的分析女性围绝经期异常子宫出血治疗中,不同激素治疗方案的实施价值。方法非随机选取2020年1月—2023年11月莘县妇幼保健院收治的88例围绝经期异常子宫出血患者为研究对象,按治疗方法不同分为两组,各44例。对照组给予单一炔诺酮片治疗、研究组在此基础上联用黄体酮胶囊治疗,比较两组患者子宫内膜厚度、血红蛋白水平、月经量、性激素指标水平及临床治疗有效率、不良反应发生情况。结果与对照组相比,研究组患者的血红蛋白水平更高,子宫内膜厚度更小、月经量更少,差异有统计学意义(P均<0.05);治疗后两组性激素指标优于治疗前,且治疗后研究组较对照组更低,差异有统计学意义(P均<0.05);研究组治疗有效率(97.73%)低于对照组(77.27%),差异有统计学意义(χ^(2)=4.838、8.416,P<0.05)。研究组不良反应发生率(2.27%)低于对照组(13.64%)。结论炔诺酮片+黄体酮胶囊联合治疗的实施效果更佳,可以帮助患者有效改善性激素指标状况,对降低子宫内膜厚度,提升血红蛋白水平具有积极意义,具有较高的应用价值。Objective To analyze the value of different hormone therapy in the treatment of abnormal uterine bleeding in perimenopausal women.Methods A total of eighty-eight patients with abnormal uterine bleeding in perimeno-pausal period admitted to Shenxian Maternal and Child Health Hospital from January 2020 to November 2023 were non-randomly selected as the study objects purposively and were divided into two groups according to different treat-ment method,with forty-four cases in each group.The control group was treated with single norethindrone tablets,and the study group was treated with progesterone capsules on this basis.The endometrial thickness,hemoglobin level,menstrual volume,sex hormone index level,clinical treatment efficiency and adverse reactions were compared be-tween the two groups.Results Compared with before treatment,the hemoglobin level in the study group was higher,endometrial thickness and menstrual volume were lower,and the differences were statistically significant(all P<0.05).After treatment,the sex hormone index of the two groups was better than that before treatment,and the study group was lower than the control group after treatment,the difference was statistically significant(all P<0.05).and the effec-tive rate of the study group(97.73%)was lower than that of the control group(77.27%),and the difference was statisti-cally significant(χ^(2)=4.838,8.416,all P<0.05).The incidence of adverse reactions in the study group(2.27%)was lower than that in the control group(13.64%).Conclusion Combined treatment with norethinone tablet and progester-one capsule has better effect,which can help patients effectively improve the status of sex hormone indicators,and has positive significance in reducing endometrial thickness and increasing hemoglobin level,and has high application value.

关 键 词：女性围绝经期异常子宫出血 不同激素治疗 子宫内膜厚度 血红蛋白 月经量 性激素指标 有效率 

分 类 号：R59[医药卫生—内科学]