冷刀宫颈锥切术对宫颈上皮内瘤样病变患者的临床效果  

Clinical Effects of Cold Knife Cervical Conization on Patients with Cervical Intraepithelial Neoplasia

作　　者：常君 秦天华 CHANG Jun;QIN Tianhua(Department of Gynecology,Urumqi First People's Hospital,Urumqi 830011,Xinjiang Uygur Autonomous Region,China;Department of Gynecology,Urumqi Maternal and Child Health Hospital,Urumqi 830000,Xinjiang Uygur Autonomous Region,China)

机构地区：[1]乌鲁木齐市第一人民医院妇科,新疆维吾尔自治区乌鲁木齐830011 [2]新疆维吾尔自治区乌鲁木齐市妇幼保健医院妇科,新疆维吾尔自治区乌鲁木齐830000

出　　处：《系统医学》2024年第12期157-160,共4页Systems Medicine

摘　　要：目的分析宫颈上皮内瘤样病变(Cervical Intraepithelial Neoplasia,CIN)患者行冷刀宫颈锥切术的临床效果。方法回顾性选取2021年1月—2023年1月乌鲁木齐市第一人民医院收治的20例CIN患者的临床资料,依据手术类型分为两组,每组10例。对照组施行宫颈环形电切术,观察组落实冷刀宫颈锥切术,对比两组治疗总有效率、手术一般指标、术后并发症发生率、术后1年内切缘阳性率、疾病复发率及妊娠率。结果两组治疗总有效率、阴道分泌物排出时间、子宫颈修复时间、术后并发症发生率、术后1年内的切缘阳性率与疾病复发率对比,差异无统计学意义(P均>0.05)。观察组的手术时间(41.51±15.89)min、住院时间(5.88±1.21)d长于对照组(15.22±5.34)min、(3.25±0.96)d,术中失血量(44.35±16.28)mL多于对照组(21.14±8.69)mL,差异有统计学意义(t=4.959、5.385、3.977,P均<0.05)。观察组术后1年内的妊娠率(70.00%)比对照组高(10.00%),差异有统计学意义(P<0.05)。结论CIN患者行宫颈环形电切术和冷刀宫颈锥切术均可取得比较理想的近远期疗效,相较而言,宫颈环形电切术的治疗时间更短,术中失血量更少,但冷刀宫颈锥切术更有利于保护患者的生育能力。Objective To analyze the clinical effect of cold knife cervical conization in patients with cervical intraepi-thelial neoplasia(CIN).Methods The clinical data of 20 patients with CIN admitted to Urumqi First People's Hospital from January 2021 to January 2023 were retrospectively selected,and they were divided into two groups according to the type of surgery,with 10 cases in each group.In the control group,loop electrosurgical excision procedure was per-formed,and in the observation group,cold knife cervical conization was implemented.Compared the total effective rate of treatment,general index of surgery,incidence of postoperative complications,positive incision margin rate,dis-ease recurrence rate and pregnancy rate in the two groups within 1 year after surgery.Results The total effective rate of treatment,time of vaginal discharge,time of cervical repair,incidence of postoperative complications,rate of posi-tive margins within 1 year postoperatively and disease recurrence rate in the two groups were compared,the differ-ences were not statistically significant(all P>0.05).The operation time(41.51±15.89)min and hospitalization time(5.88±1.21)d of the observation group were longer than those of the control group(15.22±5.34)min,(3.25±0.96)d,and intraoperative blood loss(44.35±16.28)mL was more than that of the control group(21.14±8.69)mL,and the dif-ferences were statistically significant(t=4.959,5.385,3.977,all P<0.05).The pregnancy rate within 1 year after the operation in the observation group(70.00%)was higher than in the control group(10.00%),the difference was statisti-cally significant(P<0.05).Conclusion Both loop electrosurgical excision procedure and cold knife cervical conization in patients with CIN can achieve relatively satisfactory near-and long-term therapeutic effects.In comparison,loop electrosurgical excision procedure has shorter treatment time and less intraoperative blood loss,but cold knife cervical conization is beneficial to protect the fertility of patients.

关 键 词：冷刀宫颈锥切术 宫颈上皮内瘤样病变 临床效果 

分 类 号：R4[医药卫生—临床医学]