上机前不同尿激酶封管时间在治疗隧道式血液透析导管功能不良的应用分析  

Application Analysis of Different Urokinase Sealing Time before Using Ventilator in Treatment of Poor Function of Tunnel Hemodialysis Catheters

作　　者：罗国平 LUO Guoping(Hemodialysis Room,Qingcheng District People's Hospital,Qingyuan,Guangdong 511500)

机构地区：[1]清远市清城区人民医院血透室,广东清远511500

出　　处：《智慧健康》2024年第12期74-76,79,共4页Smart Healthcare

摘　　要：目的分析上机前不同尿激酶封管时间在治疗隧道式血液透析导管功能不良的应用。方法选取2021年1—6月在本院诊治的30例隧道式血液透析导管功能不良患者为研究对象,用上机前尿激酶封管治疗,依据不同封管时间分为A组(保留20min)、B组(保留40min)和C组(保留60min),每组10例。分析各组患者透析时血流量、静脉压、尿素清除指数和导管功能不良等指标。结果与A组相比,B组和C组血流量、尿素清除指数、APTT、TT、FIB显著升高,PT下降,差异有统计学意义(P<0.05);而三组静脉压相比,差异无统计学意义(P>0.05);与A组相比,B组和C组不良发生率较高,差异有统计学意义(P<0.05)。结论通过对透析患者尿激酶封管时间进行调整,可以有效地提高隧道式血液透析患者导管功能的优良率,降低患者的凝血指标水平,同时改善血流量和静脉压。本研究旨在寻求一种简单、快速、有效的溶栓方法,以解决导管功能不良的问题,减轻患者的痛苦,从而提高透析治疗的质量。Objective To observe and analyze application of different urokinase sealing times before ventilator use in treatment of poor function of tunnel hemodialysis catheters.Methods The paper chose 30 patients with impaired function of tunnel hemodialysis catheters in our hospital from January 2021 to June 2021,treated with pre machine urokinase catheter sealing,and divided them into group A(retained for 20 minutes),group B(retained for 40 minutes),and group C(retained for 60 minutes)according to different sealing time,with 10 cases in each group.Indicators including blood flow,venous pressure,urea clearance index,and catheter dysfunction during dialysis were analyzed between groups.Results Blood flow,urea clearance index,APTT,TT,FIB,and PT in group B and group C was significantly higher than group A,with statistical difference(P<0.05).However,there was no significant difference in venous pressure among three groups.Group B and C have higher incidence of adverse events than group A,with statistical difference(P<0.05).Conclusion Choosing different urokinase sealing time before ventilator use can improve incidence of catheter dysfunction of tunnel hemodialysis patients effectively,reduce coagulation index levels,improve blood flow and venous pressure.It is necessary to find simple,fast,and effective thrombolysis methods to solve catheter dysfunction,reduce pains,and improve dialysis quality of patients.

关 键 词：上机前不同尿激酶封管时间 隧道式血液透析 导管功能不良 

分 类 号：R459.5[医药卫生—治疗学]