阿奇霉素干混悬剂结合布地奈德雾化吸入治疗小儿肺炎支原体感染性咳嗽的临床分析  

Clinical Analysis of Azithromycin Dry Suspension Combined with Budesonide Nebulized Inhalation for Mycoplasma Pneumonia Infectious Cough of Children

作　　者：孙瑶 SUN Yao(Department of Pediatrics,Nanjing City Lishui District People's Hospital,Nanjing,Jiangsu 211200)

机构地区：[1]南京市溧水区人民医院儿科,江苏南京211200

出　　处：《智慧健康》2024年第14期38-40,共3页Smart Healthcare

摘　　要：目的 探讨阿奇霉素干混悬剂联合布地奈德雾化吸入治疗小儿肺炎支原体感染性咳嗽的效果。方法 选取2022年1月—2023年7月本院收治的62例肺炎支原体感染性咳嗽患儿,利用随机数字表法分成对照组(n=31)和观察组(n=31)。对照组患儿在常规治疗基础上应用阿奇霉素干混悬剂治疗,观察组则在对照组基础上联用布地奈德治疗。对比两组患儿治疗结果。结果 两组患儿治疗前C反应蛋白(CRP)水平、肿瘤坏死因子-α(TNF-α)水平、白细胞介素-4(IL-4)水平、白细胞介素-8(IL-8)水平间不具有统计学意义(P>0.05);治疗后均改善,观察组患儿上述炎症因子水平改善程度大于对照组(P<0.05);观察组治疗有效率高于对照组治疗有效率(P<0.05)。结论 阿奇霉素干混悬剂与布地奈德雾化联用可显著降低小儿肺炎支原体感染性咳嗽患儿炎性指标,值得推广应用。Objective To explore effect of azithromycin dry suspension combined with budesonide nebulized inhalation in treatment of mycoplasma pneumoniae infectious cough of children.Methods The paper collected 62 children with mycoplasma pneumonia induced cough in our hospital from January 2022 to July 2023,and divided them into control group of 31 cases and observation group of 31 cases randomly.Control group was treated with azithromycin dry suspension based on routine treatment,while observation group with combined budesonide based on control group.Curative effect was compared between two groups.Results There was no statistically significant difference in levels of C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α),IL-4,and IL-8 between two groups before treatment,(P>0.05).After treatment,all indicators improved,levels of above inflammatory factors in observation group were better than control group(P<0.05),with statistical significance.Treatment effective rate in observation group was higher,difference was statistically significant in treatment effect rate between observation group and control group,(P<0.05).Conclusion Combination of azithromycin dry suspension and budesonide nebulization can reduce inflammatory markers of children with mycoplasma pneumoniae pneumonia induced cough significantly,which is worthy of great promotion and application.

关 键 词：肺炎支原体 感染性咳嗽 阿奇霉素干混悬剂 布地奈德 

分 类 号：R725.6[医药卫生—儿科]