行气活血止痛膏对输液性静脉炎疗效及相关炎性因子影响的实验研究  

Experimental study on effect of Xingqi Huoxue Zhitong Paste on transfusion-induced phlebitis and its impact on related inflammatory factors

作　　者：唐灵玲 冯莉 杨棋 熊璐 罗锋 李润 TANG Lingling;FENG Li;YANG Qi;XIONG Lu;LUO Feng;LI Run(the Affiliated Hospital of Traditional Chinese Medicine of Southwest Medical University,Luzhou,Sichuan,646000;Sichuan Provincial Second Hospital of Traditional Chinese Medicine,Chengdu,Sichuan,610000;School of Nursing of Southwest Medical University,Luzhou,Sichuan,646000)

机构地区：[1]西南医科大学附属中医医院,四川泸州646000 [2]四川省第二中医医院,四川成都610000 [3]西南医科大学护理学院,四川泸州646000

出　　处：《实用临床医药杂志》2024年第13期126-130,共5页Journal of Clinical Medicine in Practice

基　　金：四川省中医药管理局科学技术研究专项课题(2021MS531)。

摘　　要：目的探讨行气活血止痛膏中药外治法在静脉炎治疗中的应用效果。方法以甘露醇为致炎物,通过家兔耳缘静脉进行输注,建立静脉炎模型,将建模成功的家兔随机分为4个亚组进行干预,空白对照组常规饲养,不做任何干预处理。干预后通过观察静脉炎表征、血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、血管内皮生长因子A(VEGF-A)的含量,探讨行气活血止痛膏对甘露醇致家兔输液性静脉炎的改善作用。结果造模成功率为90.0%。治疗第1天,生理盐水组无效8例、有效1例;喜疗妥组无效6例、有效3例;硫酸镁组无效7例、有效2例;行气活血止痛膏组无效7例、有效2例;4组疗效比较,差异无统计学意义(P=0.431)。治疗第4天,生理盐水组无效5例、有效2例、显效2例;喜疗妥组有效1例、显效5例、治愈3例;硫酸镁组有效2例、显效5例、治愈2例;行气活血止痛膏组有效2例、显效4例、治愈3例。治疗第4天,与生理盐水组比较,喜辽妥组(P=0.001)、硫酸镁组(P=0.020)、行气活血止痛膏组(P=0.003)疗效差异均有统计学意义;硫酸镁组、行气活血止痛膏组疗效与喜疗妥组比较,差异均无统计学意义(P>0.05);与硫酸镁组比较,喜疗妥组、行气活血止痛膏组疗效差异均无统计学意义(P>0.05);与行气活血止痛膏组比较,喜疗妥组、硫酸镁组疗效差异均无统计学意义(P>0.05);生理盐水组治疗有效率为11.1%,治愈率为0%,喜辽妥组有效率为100.0%,治愈率为33.3%,硫酸镁组有效率为77.7%,治愈率为44.4%,行气活血止痛膏组有效率为66.7%,治愈率为22.2%。行气活血止痛膏组、喜疗妥组、硫酸镁组药物有效率高于生理盐水组,差异有统计学意义(P<0.05)。干预后,4个模型亚组血清炎性因子IL-6、TNF-α、VEGF-A水平与空白对照组比较,差异均有统计学意义(P<0.05);生理盐水组与喜辽妥组、硫酸镁组、行气活血止痛膏组血清炎性因子IL-6、TNF-α、VObjective To investigate the application effect of external treatment method of Xingqi Huoxue Zhitong Paste in the treatment of phlebitis.Methods Using mannitol as an inflammatory agent,a phlebitis model was established by infusion into the ear marginal vein of rabbits.Successfully modeled rabbits were randomly divided into four subgroups for intervention,while the blank control group was routinely raised without any intervention.After the intervention,the improvement effect of Xingqi Huoxue Zhitong Paste on mannitol-induced transfusion-induced phlebitis in rabbits was explored by observing the manifestations of phlebitis,serum interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and vascular endothelial growth factor A(VEGF-A)levels.Results The success rate was up to 90.0%.On the first day of treatment,there were 8 ineffective cases and 1 effective case in the saline group;6 ineffective cases and 3 effective cases in the hirudoid group;7 ineffective cases and 2 effective cases in the magnesium sulfate group;7 ineffective cases and 2 effective cases in the Xingqi Huoxue Zhitong Paste group.There was no significant difference in the curative effect among the four groups(P=0.431).On the fourth day of treatment,there were 5 ineffective cases,2 effective cases,and 2 markedly effective cases in the saline group;1 effective case,5 markedly effective cases,and 3 cured cases in the hirudoid group;2 effective cases,5 markedly effective cases,and 2 cured cases in the magnesium sulfate group;2 effective cases,4 markedly effective cases,and 3 cured cases in the Xingqi Huoxue Zhitong Paste group.On the fourth day of treatment,compared with the saline group,the curative effects of the hirudoid group(P=0.001),the magnesium sulfate group(P=0.020),and the Xingqi Huoxue Zhitong Paste group(P=0.003)were statistically significant.There was no significant difference in curative effect in the magnesium sulfate group and the Xingqi Huoxue Zhitong Paste group when compared with the hirudoid group(P>0.05);there was no significant differe

关 键 词：静脉炎 行气活血止痛膏 抗炎 血清炎性因子 

分 类 号：R543.6[医药卫生—心血管疾病] R364.5[医药卫生—内科学] R242[医药卫生—临床医学]