定坤丹与来曲唑治疗PCOS对患者超声指标及炎症因子影响  

Effects of Dingkundan and Letrozol on Ultrasound indicators and Inflammatory Factors in Patients with PCOS

作　　者：危娟萍 钟柏林 危丽 WEI Juanping;ZHONG Bolin;WEI Li(Gynecology Department,Ruijin Maternal and Child Health Hospital,Ruijin 342500,China;不详)

机构地区：[1]瑞金市妇幼保健院妇科,江西瑞金342500

出　　处：《中国医学创新》2024年第22期133-137,共5页Medical Innovation of China

摘　　要：目的:探讨定坤丹与来曲唑联合治疗多囊卵巢综合征(PCOS)患者对其超声指标、性激素及血清促炎因子的影响。方法:将2020年7月—2023年1月瑞金市妇幼保健院的78例PCOS患者纳入研究,使用随机法分为定坤丹组(n=26)、来曲唑组(n=26)、联合组(n=26),三组均接受相应治疗三个周期。比较三组卵巢大小、卵泡数量、内膜厚度等超声指标,以及血清性激素[卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E_(2))和睾酮(T)]、促炎因子[肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)]的水平。结果:治疗前,三组超声指标(卵泡数量、子宫内膜厚度、卵巢体积)、FSH、LH、E_(2)和T的水平,以及TNF-α、CRP水平比较,差异均无统计学意义(P>0.05)。治疗后,联合组卵泡数量、子宫内膜厚度及卵巢体积均显著优于定坤丹组和来曲唑组,差异均有统计学意义(P<0.05)。治疗后,三组FSH、E_(2)水平较治疗前比较,差异均无统计学意义(P>0.05),三组LH、T水平较治疗前均显著下降,联合组低于定坤丹组与来曲唑组,差异均有统计学意义(P<0.05)。治疗后,三组TNF-α和CRP水平较治疗前均降低,联合组低于定坤丹组与来曲唑组,差异均有统计学意义(P<0.05)。结论:定坤丹与来曲唑联合治疗可有效改善PCOS患者的超声指标,调整性激素水平,并降低血清促炎因子的水平,为临床治疗PCOS提供了新的策略。Objective:To investigate the effects of Dingkundan combined with Letrozol on ultrasound indicators,sex hormones,and serum pro-inflammatory factors in patients with polycystic ovary syndrome(PCOS).Method:A total of 78 PCOS patients from Ruijin Maternal and Child Health Hospital from July 2020 to January 2023 were included in the study,and randomly divided into three groups:Dingkundan group(n=26),Letrozol group(n=26),and combination group(n=26).All three groups received corresponding treatment for three cycles.Ultrasound indicators such as ovarian size,follicle count,and endometrial thickness,the levels of serum sex hormones[follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E_(2)),and testosterone(T)]and pro-inflammatory factors[tumor necrosis factor-α(TNF-α),C reactive protein(CRP)]were compared among three groups.Result:Before treatment,there were no statistically significant differences in ultrasound indicators(follicle count,endometrial thickness,ovarian volume),FSH,LH,E_(2),and T levels,as well as TNF-α and CRP levels among the three groups of patients(P>0.05).After treatment,number of follicles,endometrial thickness,and ovarian volume in the combination group were significantly better than those in the Dingkundan group and the Letrozol group,the differences were statistically significant(P<0.05).After treatment,there were no statistically significant differences in FSH and E_(2) levels among the three groups compared to those before treatment(P>0.05);LH and T levels in all three groups were decreased significantly compared to those before treatment,and those in the combination group were lower than those in the Dingkundan group and the Letrozol group,the differences were statistically significant(P<0.05).After treatment,the levels of TNF-α and CRP in all three groups were decreased compared to those before treatment,and those in the combination group were lower than those in the Dingkundan group and the Letrozol group,the differences were statistically significant(P<0.05).Conclusion:The

关 键 词：定坤丹 来曲唑 多囊卵巢综合征 超声指标 性激素 血清促炎因子 

分 类 号：R711.75[医药卫生—妇产科学] R445.1[医药卫生—临床医学]