基于泊洛沙姆的温敏凝胶在局部药物递送系统中的应用  

Application of Temperature-sensitive Gel Based on Poloxamer in Local Drug Delivery Systems

作　　者：王晶 邓丽菁[2] 曾韵 WANG Jing;DENG Lijing;ZENG Yun(Department of Pharmacy,Xiamen Children's Hospital,Xiamen 361006,China;不详)

机构地区：[1]厦门市儿童医院(复旦大学附属儿科医院厦门医院)药学部,福建厦门361006 [2]南华大学附属第一医院科研与学科建设部,湖南衡阳421001

出　　处：《中国医学创新》2024年第22期183-188,共6页Medical Innovation of China

基　　金：湖南省自然科学基金联合基金项目(2023JJ60364);厦门市自然科学基金(3502Z202372098)。

摘　　要：温度敏感型的原位凝胶因其能根据温度变化进行相转变的特性而受到临床上的广泛关注,其在室温下为液体,在接近人体温度时能够快速形成凝胶,因此具有易于给药、缓释药物的特点。近年来,温敏凝胶作为一种局部药物递送系统的相关研究日益增多,而其中泊洛沙姆因具有良好的生物相容性和无毒性,基于泊洛沙姆制备的温敏凝胶占大多数。本文主要介绍了基于泊洛沙姆的温敏凝胶在局部药物递送系统中的开发和应用。Temperature-sensitive in situ gels have attracted wide clinical attention because of their ability to undergo phase transformation according to temperature changes.It is a liquid at room temperature and can quickly form a gel when it is close to human body temperature,so it has the characteristics of easy administration and sustained release of drugs.In recent years,there have been more and more researches on temperature-sensitive gels as a local drug delivery system,among which temperature-sensitive gels based on Poloxamer account for the majority due to their good biocompatibility and non-toxicity.This paper mainly introduces the development and application of temperature-sensitive gel based on Poloxamer in local drug delivery system.

关 键 词：泊洛沙姆 温敏凝胶 局部给药 

分 类 号：R943[医药卫生—药剂学]