心房颤动患者经皮冠状动脉介入后的抗血栓潜在生物标志物和治疗靶点的综合分析  

Comprehensive Analysis of Potential Antithrombotic Biomarkers and Therapeutic Targets of Patients with Atrial Fibrillation After Percutaneous Coronary Intervention

作　　者：李景瑞[1] 吴晓杰[1] 信鸿巍 张百会 丁园园 LI Jingrui;WU Xiaojie;XIN Hongwei;ZHANG Baihui;DING Yuanyuan(Qiqihar Medical College the Second Affiliated Hospital,Qiqihar,Heilongjiang 161006)

机构地区：[1]齐齐哈尔医学院附属第二医院,黑龙江齐齐哈尔161006

出　　处：《智慧健康》2024年第13期48-50,共3页Smart Healthcare

摘　　要：目的探究治疗靶点对于房颤患者经皮冠状动脉介入术(PCI)后血栓形成的预测效能。方法选择某医院2022年7月—2023年7月收治的120例进行PCI术治疗的房颤患者为研究对象,根据术后14d内是否出现血栓将其分为血栓组(44例)和无血栓组(76例)。收集对比两组的一般临床资料,分析影响房颤患者PCI术后血栓形成的危险因素,探究关键性靶点的临床预测效能。结果与无血栓组相比,血栓组原发性高血压患者占比、vWT和D-D水平更高,差异有统计学意义(P<0.05),两组其余资料比较,差异无统计学意义(P>0.05);原发性高血压、vWF和D-D水平是房颤患者PCI术后出现血栓的独立危险因素,差异有统计学意义(P<0.05)。结论临床对存在原发性高血压病史的患者及其vWT和D-D水平进行密切监测,可有效预测房颤患者PCI术后发生血栓的可能性,改善患者预后。Objective To explore predictive effect of therapeutic targets for thrombosis formation of patients with atrial fibrillation after percutaneous coronary intervention(PCI).Methods The paper chose 120 patients with atrial fibrillation with PCI treatment in a hospital from July 2022 to July 2023 as study subjects,and divided them into thrombotic group(44 cases)and non thrombotic group(76 cases)based on thrombosis condition within 14 days after surgery.General clinical data were collected and compared between two groups,risk factors affecting thrombosis formation of patients with atrial fibrillation after PCI were analyzed,and clinical predictive effect of key targets was explored.Results Thrombotic group had higher proportion of primary hypertension,higher vWT and D-D levels than non thrombotic group,(P<0.05),with no difference in other data between two groups(P>0.05).Primary hypertension,vWF,and D-D levels are independent risk factors of thrombosis for patients with atrial fibrillation after PCI(P<0.05).Conclusion Close monitoring of vWT and D-D levels can provide predictive effect and improve prognosis of thrombosis patients after PCI with primary hypertension history in clinical practice effectively.

关 键 词：心房颤动 经皮冠状动脉介入 抗血栓 关键性靶点 

分 类 号：R541.75[医药卫生—心血管疾病]