化湿降浊饮配合三黄散外敷对痛风性关节炎患者的影响  

Effects of Huashi Jiangzhuo Decoction Combined with Sanhuang Powder for External Application on Patients with Gouty Arthritis

作　　者：陈勇 王毅峰 CHEN Yong;WANG Yifeng(Orthopedics and Traumatology Department,Lujiang Branch of Siming Hospital,the First Affiliated Hospital of Xiamen University,Xiamen 361000,China;不详)

机构地区：[1]厦门大学附属第一医院思明院区鹭江分部骨伤科,福建厦门361000

出　　处：《中国医学创新》2024年第20期63-68,共6页Medical Innovation of China

基　　金：福建省卫生健康委员会科技计划项目(2021QNB047)。

摘　　要：目的:探讨化湿降浊饮配合三黄散外敷对痛风性关节炎(GA)患者的影响。方法:选取2022年2月—2024年2月厦门大学附属第一医院思明院区鹭江分部收治的86例GA患者作为研究对象,随机分为内外联合组和单纯外敷组,各43例。单纯外敷组给予三黄散外敷治疗,内外联合组予以化湿降浊饮内服配合三黄散外敷治疗,均治疗4周。比较两组中医症候积分、疼痛缓解情况、炎症因子[C反应蛋白(CRP)、红细胞沉降率(ESR)、血尿酸]、临床疗效、生活质量(QOL)评分及不良反应发生情况。结果:治疗后,内外联合组中医症候积分、数字分级评分法(NRS)评分、ESR、CRP、UR水平均显著低于单纯外敷组,差异均有统计学意义(P<0.05)。内外联合组的临床总有效率(95.35%)显著高于单纯外敷组(81.40%),差异有统计学意义(P<0.05)。治疗后内外联合组QOL评分高于单纯外敷组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:化湿降浊饮配合三黄散外敷治疗GA患者能有效改善患者中医症候,缓解疼痛等临床症状,有效降低患者ESR、CRP、血尿酸水平,从而提高临床疗效,并可有效改善患者生活质量,不增加不良反应。Objective:To explore the effect of Huashi Jiangzhuo Decoction combined with external application of Sanhuang Powder on gouty arthritis(GA)patients.Method:A total of 86 GA patients admitted to Lujiang Branch of Siming Hospital,the First Affiliated Hospital of Xiamen University from February 2022 to February 2024 were selected as the study objects and randomly divided into internal and external combination group and simple external application group,with 43 cases in each group.The simple external application group was treated with external application of Sanhuang Powder,and the internal and external combination group was treated with internal administration of Huashi Jiangzhuo Decoction combined with external application of Sanhuang Powder,all were treated for 4 week.Traditional Chinese medicine symptom score,pain relief,inflammatory factors[C reactive protein(CRP),erythrocyte settlement rate(ESR),serum uric acid],clinical efficacy,quality of life(QOL)score and occurrence of adverse reactions were compared between the two groups.Result:After treatment,the traditional Chinese medicine syndrome score,numerical rating scale(NRS)score,ESR,CRP and serum uric acid levels of the internal and external combination group were significantly lower than those of the simple external application group,the differences were statistically significant(P<0.05).The total clinical effective rate of the internal and external combination group(95.35%)was significantly higher than that of the simple external application group(81.40%),the difference was statistically significant(P<0.05).After treatment,the QOL score of the internal and external combination group was higher than that of the simple external application group,the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Huashi Jiangzhuo Decoction combined with external application of Sanhuang Powder can effectively improve traditional Chinese medicine syndromes,alle

关 键 词：化湿降浊饮 三黄散 痛风性关节炎 临床症状 C反应蛋白 红细胞沉降率 血尿酸 

分 类 号：R259[医药卫生—中西医结合]