癃清胶囊联合盐酸坦索罗辛治疗湿热下注型慢性非细菌性前列腺炎的效果  

The Effect of Longqing Capsules Combined with Tamsulosin Hydrochloride in the Treatment of Chronic Nonbacterial Prostatitis with Damp Heat Infusion Type

作　　者：季晨 章毅 王幸畑 JI Chen;ZHANG Yi;WANG Xingtian(Urology Department,Fujian University of Traditional Chinese Medicine Affiliated People's Hospital,Fuzhou 350004,China;不详)

机构地区：[1]福建中医药大学附属人民医院泌尿外科,福建福州350004

出　　处：《中国医学创新》2024年第20期74-77,共4页Medical Innovation of China

摘　　要：目的:观察癃清胶囊联合盐酸坦索罗辛治疗湿热下注型慢性非细菌性前列腺炎(CNP)的效果。方法:将2021年1月—2024年1月就诊于福建中医药大学附属人民医院泌尿外科80例湿热下注型CHP患者随机分为联合治疗组(n=40),对照组(n=40)。联合治疗组口服癃清胶囊联合盐酸坦索罗辛缓释胶囊治疗,对照组口服盐酸坦索罗辛缓释胶囊,均治疗1个月。观察两组临床治疗效果、血清白细胞介素-6(IL-6),前列腺液(EPS)中白细胞的变化及慢性前列腺炎症状评分表(NIH-CPSI)评分。结果:联合治疗组总有效率为90.00%、对照组总有效率为67.50%,联合治疗组的临床总有效率明显高于对照组,差异有统计学意义(χ^(2)=6.050,P=0.014)。治疗后,联合治疗组与对照组在疼痛或不适症状[(2.10±0.98)分vs(4.23±1.31)分]、排尿症状[(3.23±0.73)分vs(4.73±0.91)分]、生活质量[(3.73±0.99)分vs(4.68±1.07)分]及CPSI总评分[(9.05±1.45)分vs(13.63±1.60)分]均有明显改善,差异均有统计学意义(P<0.05)。治疗后,联合治疗组与对照组白细胞数量均较治疗前明显减少(P<0.05),且联合治疗组白细胞相比对照组白细胞明显减少[(5.53±1.34)个/HP vs(7.73±1.60)个/HP],差异有统计学意义(t=-6.665,P=0.001)。治疗后,两组炎症因子IL-6均低于治疗前,联合治疗组的IL-6与对照组相比明显下降[(6.12±1.43)pg/mL vs(7.98±0.99)pg/mL],差异均有统计学意义(P<0.05),临床观察期间所有患者均未出现明显不良反应。结论:癃清胶囊联合盐酸坦索罗辛缓释胶囊对湿热下注型慢性非细菌性前列腺炎患者治疗有效,可改善生活质量,并且安全性高。Objective:To observe the effect of Longqing Capsules combined with Tamsulosin Hydrochloride in the treatment of chronic nonbacterial prostatitis(CNP)with damp heat infusion type.Method:A total of 80 patients with damp heat infusion type CNP who visited the Urology Department of Fujian University of Traditional Chinese Medicine Affiliated People's Hospital from January 2021 to January 2024 were randomly divided into a combination treatment group(n=40)and a control group(n=40).Combination treatment group received oral Longqing Capsules combined with Tamsulosin Hydrochloride Sustained Release Capsules,while the control group received oral Tamsulosin Hydrochloride Sustained Release Capsules,the treatment period was one month.The clinical treatment effect of the patient,serum interleukin-6(IL-6),changes in white blood cells in expressed prostatic secretions(EPS),and the national institutes of health-chronic prostatitis symptom index(NIH-CPSI)score were observed between two groups.Result:The total effective rate of the combination treatment group was 90.00%,while the total effective rate of the control group was 67.50%,the total clinical effective rate of the combination treatment group was significantly higher than that of the control group,the difference was statistically significant(χ^(2)=6.050,P=0.014).After treatment,the combination treatment group and the control group were significant improved in pain or discomfort symptoms[(2.10±0.98)points vs(4.23±1.31)points],urinary symptoms[(3.23±0.73)points vs(4.73±0.91)points],quality of life[(3.73±0.99)points vs(4.68±1.07)points],and CPSI total score[(9.05±1.45)points vs(13.63±1.60)points],the differences were statistically significant(P<0.05).After treatment,the number of white blood cells in the prostate fluid of patients in the combination treatment group and the control group was significantly reduced compared to those before treatment(P<0.05),and the white blood cells in the combination treatment group was significantly reduced compared to the control group

关 键 词：慢性非细菌性前列腺炎 癃清胶囊 湿热 

分 类 号：R697.33[医药卫生—泌尿科学]