甲氨蝶呤联合托法替布用于活动性类风湿关节炎的效果  

The Effect of Methotrexate Combined with Tofacitinib on Active Rheumatoid Arthritis

作　　者：赵黾 ZHAO Min(Rheumatology and Immunology Department,Xinyu People's Hospital,Xinyu 338000,China)

机构地区：[1]新余市人民医院风湿免疫科,江西新余338000

出　　处：《中国医学创新》2024年第21期40-43,共4页Medical Innovation of China

摘　　要：目的:探讨甲氨蝶呤联合托法替布用于活动性类风湿关节炎的效果。方法:将2022年1—12月新余市人民医院接收的60例活动性类风湿关节炎患者进行研究,选择随机数字表法将其分成两组,各30例。对照组采用甲氨蝶呤治疗,观察组在对照组的基础治疗上联合托法替布治疗,所有患者均治疗6个月。观察两组治疗效果、炎症指标、28关节活动度(DAS28)评分、血清学指标、不良反应发生情况。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。干预前,观察组和对照组红细胞沉降率(ESR)、C反应蛋白(CRP)水平比较,差异均无统计学意义(P>0.05);干预后,观察组和对照组ESR、CRP水平均低于干预前,且观察组均低于对照组,差异均有统计学意义(P<0.05)。干预前,观察组和对照组DAS28评分比较,差异无统计学意义(P>0.05);干预后,观察组和对照组DAS28评分均低于干预前,而且观察组低于对照组(P<0.05)。干预前后,观察组和对照组白细胞(WBC)、血红蛋白(HGB)、血小板(PLT)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、尿酸(UA)、血尿素氮(BUN)水平比较,差异均无统计学意义(P>0.05)。观察组和对照组胃肠道反应、肝功能受损、白细胞下降、皮肤质变、发热等发生率对比,差异无统计学意义(P>0.05)。结论:甲氨蝶呤联合托法替布用于活动性类风湿关节炎的效果比较明显,对比来看,患者经联合托法替布治疗后,DAS28评分有明显改善。Objective:To explore the efficacy of Methotrexate combined with Tofacitinib in the treatment of active rheumatoid arthritis.Method:A total of 60 patients with active rheumatoid arthritis admitted to Xinyu People's Hospital from January to December 2022,they were divided into two groups by random number table method,with 30 cases in each group.Control group was treated with Methotrexate treatment,observation group was treated with combined treatment with Tofacitinib in addition to the basic treatment in the control group,all patients were treated for 6 months.The treatment efficacy,inflammation indicators,28 disease activity score in 28 joints(DAS28),serological indicators and occurrence of adverse reactions were observed in the two groups.Result:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).There were no statistically significant differences in the levels of erythrocyte sedimentation rate(ESR),C reactive protein(CRP)between the observation group and the control group before intervention(P>0.05);after intervention,the levels of ESR,CRP in the observation group and control group were lower than those before intervention,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before intervention,there was no statistically significant difference between the observation group and the control group in DAS28 score(P>0.05);after intervention,DAS28 scores in the observation group and control group were lower than those before intervention,and that in the observation group was lower than that in the control group,the differences were statistically significant(P<0.05).There were no statistically significant differences in the levels of white blood cells(WBC),hemoglobin(HGB),platelets(PLT),alanine aminotransferase(ALT),aspartate aminotransferase(AST),uric acid(UA)and blood urea nitrogen(BUN)between the observation group and the control group before and

关 键 词：甲氨蝶呤 托法替布 活动性类风湿关节炎 

分 类 号：R593.22[医药卫生—内科学]