生长抑素联合双氯芬酸钠对内镜逆行胰胆管造影术后轻中度胰腺炎的临床效果  

Clinical Effect of Somatostatin Combined with Diclofenac Sodium on Mild to Moderate Pancreatitis after Endoscopic Retrograde Cholangiopancreatography

作　　者：熊日晖 陈伟力[1] 吴兆平[1] 袁国辉 XIONG Rihui;CHEN Weili;WU Zhaoping;YUAN Guohui(不详;Department of Hepatobiliary Surgery,Jiujiang NO.1 People's Hospital,Jiujiang 332000,China)

机构地区：[1]九江市第一人民医院肝胆胰外科,江西九江332000

出　　处：《中国医学创新》2024年第21期48-52,共5页Medical Innovation of China

基　　金：江西省中医药管理局科技计划项目(2021B253)。

摘　　要：目的:探究生长抑素联合双氯芬酸钠对内镜逆行胰胆管造影(ERCP)术后胰腺炎患者的临床价值。方法:将2022年3月—2024年3月在九江市第一人民医院经ERCP治疗后继发轻中度胰腺炎的患者86例,按随机数字表法将患者分为常规组和研究组,各43例。常规组给予抗感染、补充体液、控制饮食和胃肠道减压等常规基础治疗,研究组在此基础上联合生长抑素和双氯芬酸钠进行治疗。观察两组临床有效情况,比较两组血清淀粉酶(AMS)、脂肪酶指标;记录两组炎症因子[白细胞介素6(IL-6)和C反应蛋白(CRP)]水平变化和不良反应。结果:常规组临床总有效率[72.09%(31/43)]显著低于研究组[90.70%(39/43)],差异有统计学意义(P<0.05)。治疗前,两组AMS、脂肪酶指标比较,差异均无统计学意义(P>0.05);治疗后,两组AMS、脂肪酶指标较治疗前均有下降,且研究组下降均更显著,差异均有统计学意义(P<0.05)。治疗前,两组IL-6和CRP水平比较,差异均无统计学意义(P>0.05);治疗后,两组IL-6和CRP水平均较治疗前下降,且研究组下降均更显著,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:相较于常规疗法,生长抑素联合双氯芬酸钠对ERCP术后胰腺炎患者效果更显著,可以显著降低胰腺炎患者AMS、脂肪酶指标和炎症因子水平,且安全性好。Objective:To explore the clinical value of Somatostatin combined with Diclofenac Sodium in patients with pancreatitis after endoscopic retrograde cholangiopancreatography(ERCP).Method:A total of 86 patients who developed mild to moderate pancreatitis after ERCP and were admitted to Jiujiang NO.1 People's Hospital from March 2022 to March 2024 were divided into the conventional group and the study group by the random number table method,with 43 patients in each group.The conventional group was given conventional basic treatments such as anti-infection treatment,fluid supplementation,dietary control and gastrointestinal decompression,on this basis,the study group was treated with Somatostatin and Diclofenac Sodium.Clinical efficacy in the two groups was observed;serum amylase(AMS)and lipase were compared between two groups;changes in the levels of inflammatory factors[interleukin-6(IL-6)and C reactive protein(CRP)]and adverse reactions in both groups were recorded.Result:The clinical total effective rate of the conventional group[72.09%(31/43)]was significantly lower than that of the study group[90.70%(39/43)],the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in AMS and lipase indicators between the two groups(P>0.05);after treatment,the AMS and lipase indicators in both groups were decreased compared to those before treatment,and the decrease was more significant in the study group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in IL-6 level and CRP level between the two groups(P>0.05);after treatment,the levels of IL-6 and CRP in both groups were decreased compared to those before treatment,and the decrease was more significant in the study group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Compared with conventional treatment,Somatostatin combined with Dic

关 键 词：生长抑素 双氯芬酸钠 内镜逆行胰胆管造影术 胰腺炎 

分 类 号：R657.51[医药卫生—外科学]