中药治疗女童性早熟的临床效果  

The Clinical Effect of Traditional Chinese Medicine in the Treatment of Precocious Puberty in Little Girls

作　　者：喻妮娜 陈绍红[1] 徐萍[1] 陈莉莉[2] 朱华[1] 龚盼盼 刘晓艳 陈雯 陈洁汝 熊艳丽 YU Nina;CHEN Shaohong;XU Ping;CHEN Lili;ZHU Hua;GONG Panpan;LIU Xiaoyan;CHEN Wen;CHEN Jieru;XIONG Yanli(不详;Department of Children's Health,Jiangxi Maternal and Child Health Hospital,Nanchang 330006,China)

机构地区：[1]江西省妇幼保健院儿童保健科,江西南昌330006 [2]江西省妇幼保健院中医科,江西南昌330006

出　　处：《中国医学创新》2024年第21期89-93,共5页Medical Innovation of China

基　　金：江西省中医药管理局科技计划项目(2023B0481)。

摘　　要：目的:分析中药治疗女童性早熟的临床效果。方法:选择2020年3月—2023年9月在江西省妇幼保健院接受体检的乳房早发育的80例女童为研究对象,以诊断结果为依据分为A组、B组。诊断为不完全性性早熟的43例患儿为A组,以随机数字表法分为两组,观察A组21例,对照A组22例。诊断为特发性中枢性性早熟的37例患儿为B组,以随机数字表法分为2组,观察B组18例,对照B组19例。对照A组和对照B组选择知柏地黄丸治疗,观察A组和观察B组在知柏地黄丸治疗的基础上加用大补阴丸治疗。比较临床效果,乳房、子宫、卵巢大小,骨龄指数及不良反应发生率。结果:观察A组总有效率高于对照A组,观察B组总有效率高于对照B组,差异均有统计学意义(P<0.05)。与治疗前相比,四组治疗后乳核直径均缩短,子宫容积、卵巢容积均较治疗前减少,且观察A组均优于对照A组,观察B组均优于对照B组,差异均有统计学意义(P<0.05)。观察A组、观察B组骨龄指数均低于治疗前(P<0.05);对照A组、对照B组骨龄指数与治疗前比较,差异均无统计学意义(P>0.05);治疗后,观察A组低于对照A组,观察B组低于对照B组,差异均有统计学意义(P<0.05)。对照A组与观察A组不良反应发生率相比,对照B组与观察B组相比,差异均无统计学意义(P>0.05)。结论:相比较知柏地黄丸,大补阴丸联合知柏地黄丸治疗不完全性性早熟和特发性中枢性性早熟女童的效果更佳,能够显著改善患儿的体征,抑制早熟症状,延缓骨骼成熟,应用价值较高。Objective:To analyze the clinical efficacy of traditional Chinese medicine in the treatment of precocious puberty in little girls.Method:A total of eighty little girls with premature thelarche who underwent physical examinations in Jiangxi Maternal and Child Health Hospital from March 2020 to September 2023 were selected as the research subjects,and they were divided into group A and group B based on the diagnostic results.A total of 43 children diagnosed with incomplete precocious puberty were selected as group A and divided into two groups by random number table method,with 21 cases in the observation group A and 22 cases in the control group A.A total of 37 children diagnosed with idiopathic central precocious puberty were selected as group B and divided into two groups by random number table method,with 18 cases in the observation group B and 19 cases in the control group B.Control group A and control group B were treated with Zhibai Dihuang Pills,observation group A and observation group B with the addition of Dabuyin Pills on the basis of Zhibai Dihuang Pills treatment.The clinical efficacy,sizes of breast,uterine,and ovarian,bone age index,and incidence of adverse reactions were compared.Result:The total effective rate of observation group A was higher than that of control group A,and the total effective rate of observation group B was higher than that of control group B,the differences were statistically significant(P<0.05).Compared with before treatment,the diameter of the mammary nucleus in all four groups after treatment were decreased,and the uterine and ovarian volumes were decreased,those in observation group A were better than those in control group A,and those in observation group B were better than those in control group B,the differences were statistically significant(P<0.05).The bone age index of observation group A and observation group B were lower than those before treatment(P<0.05);there were no statistically significant differences in control group A and control group B compared with those

关 键 词：知柏地黄丸 大补阴丸 不同类型 性早熟 

分 类 号：R272[医药卫生—中医儿科学]