玻璃体视网膜界面巨噬细胞样细胞的研究进展  

Research progress on macrophage-like cells at vitreoretinal interface

作　　者：陈紫晴 王柯[2] 邹文军 CHEN Ziqing;WANG Ke;ZOU Wenjun(Department of Ophthalmology,Wuxi Second Hospital Affiliated to Nanjing Medical University,Wuxi,Jiangsu,214002;Functional Protein Research Group of Jiangsu Institute of Atomic Medicine,Wuxi,Jiangsu,214063;Department of Ophthalmology,Medical Center Affiliated to Jiangnan University,Wuxi,Jiangsu,214002)

机构地区：[1]南京医科大学附属无锡第二医院眼科,江苏无锡214002 [2]江苏省原子医学研究所功能蛋白课题组,江苏无锡214063 [3]江南大学附属中心医院眼科,江苏无锡214002

出　　处：《实用临床医药杂志》2024年第11期139-143,共5页Journal of Clinical Medicine in Practice

基　　金：江苏省博士后科研资助项目(2021K196B);江苏省无锡市“双百”中青年医疗卫生拔尖人才项目(BJ2023036)。

摘　　要：巨噬细胞样细胞(MLCs)是一类具有免疫功能的异质性细胞群,主要包括小胶质细胞、玻璃体细胞以及血浆单核-巨噬细胞等。在生理情况下,MLCs参与视网膜稳态维持,在病理情况下则参与视网膜炎性病变,如糖尿病视网膜病变、视网膜静脉阻塞、葡萄膜炎等。2020年,CASTANOS M V等首次使用临床光学相干层析成像(OCT)仪器将玻璃体视网膜界面MLCs可视化,至此越来越多的研究小组将其应用于各种视网膜及脉络膜炎性疾病的研究。本研究针对MLCs的一般特征以及其在各种视网膜及脉络膜炎性疾病中的研究进展进行阐述。Macrophage-like cells(MLCs)are a heterogeneous group of cells with immune functions,mainly including microglia,vitreous cells,and plasma monocytes-macrophages.Under physiological conditions,MLCs participate in maintaining the homeostasis of the retina,and under pathological conditions,they participate in inflammatory lesions of the retina,such as diabetic retinopathy,retinal vein occlusion,and uveitis.In 2020,researcher represented by CASTANOS MV and others firstly used clinical optical coherence tomography(OCT)instruments to visualize MLCs at the vitreoretinal interface,and since then,more and more research teams have applied it to the study of various retinal and choroidal inflammatory diseases.This study elaborated on the general characteristics of MLCs and their research progress in various retinal and choroidal inflammatory diseases.

关 键 词：小胶质细胞 光学相干层析成像 巨噬细胞样细胞 糖尿病视网膜病变 视网膜静脉阻塞 葡萄膜炎 

分 类 号：R828.7[医药卫生—临床医学] R776.4R774.1