富血小板血浆联合氨糖美辛肠溶片治疗早中期膝骨关节炎患者的效果  

Effects of platelet rich plasma combined with Glucosamine indometacin enteric-coated tablets in treatment of patients with early and middle knee osteoarthritis

作　　者：宋永攀 李照义 SONG Yongpan;LI Zhaoyi(Department of Orthopaedics of Dengzhou People’s Hospital,Nanyang 474150 Henan,China)

机构地区：[1]邓州市人民医院骨科,河南南阳474150

出　　处：《中国民康医学》2024年第15期52-55,共4页Medical Journal of Chinese People’s Health

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20200995)。

摘　　要：目的:观察富血小板血浆(PRP)联合氨糖美辛肠溶片治疗早中期膝骨关节炎(KOA)患者的效果。方法:回顾性分析2022年1月至2023年1月该院收治的96例早中期KOA患者的临床资料,根据治疗方案不同将其分为对照组和研究组各48例。对照组予以氨糖美辛肠溶片治疗,研究组在对照组基础上联合PRP治疗。比较两组临床疗效,治疗前后关节功能[膝关节功能评分表(Lysholm)、骨关节炎指数量表(WOMAC)]评分、关节滑液炎性因子[白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)]水平、关节滑液基质代谢相关指标[基质金属蛋白酶-3(MMP-3)、基质金属蛋白酶-13(MMP-13)、透明质酸(HA)]水平、血清微小RNA-140(miR-140)和微小RNA-365(miR-365)水平。结果:研究组治疗总有效率为91.67%(44/48),高于对照组的72.92%(35/48),差异有统计学意义(P<0.05);治疗后,研究组Lysholm评分高于对照组,WOMAC评分低于对照组,差异均有统计学意义(P<0.05);治疗后,研究组关节滑液IL-6、IL-1β、TNF-α、MMP-3、MMP-13水平均低于对照组,HA水平高于对照组,差异有统计学意义(P<0.05);治疗后,研究组血清miR-140水平高于对照组,miR-365水平低于对照组,差异均有统计学意义(P<0.05)。结论:PRP联合氨糖美辛肠溶片治疗早中期KOA患者可提高治疗总有效率和miR-140水平,改善关节功能评分和关节滑液基质代谢相关指标水平,降低关节滑液炎性因子和miR-365水平,效果优于单纯氨糖美辛肠溶片治疗。Objective:To observe effects of platelet rich plasma(PRP)combined with Glucosamine indometacin enteric-coated tablets in treatment of patients with early and middle knee osteoarthritis(KOA).Methods:The clinical data of 96 patients with early and middle stage KOA admitted to the hospital from January 2022 to January 2023 were retrospectively analyzed.According to different treatment options,they were divided into control group and study group,48 cases in each group.The control group was treated with Glucosamine indometacin enteric-coated tablets,while the study group was treated with PRP on the basis of that of the control group.The clinical efficacy,the joint function[knee joint function scale(Lysholm),Western Ontario and McMaster University of orthopedic index(WOMAC)]score,the joint synovialfluid inflammatory factors[interleukin-6(IL-6),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)]levels,the joint synovialfluid matrix metabolism related indicators[matrix metalloproteinase-3(MMP-3),matrix metalloproteinase-13(MMP-13),hyaluronic acid(HA)]levels,the serum microRNA-140(miR-140),and the microRNA-365(miR-365)levels were compared between the two groups before and after the treatment.Results:The total effective rate of the study group was 91.67%(44/48),which was higher than 72.92%(35/48)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the Lysholm score of the study group was higher than that of the control group,the WOMAC score was lower than that of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,IL-1β,TNF-α,MMP-3 and MMP-13 in the synovialfluid of the study group were lower than those in the control group,the level of HA was higher than that in the control group,and the differences were statistically significant(P<0.05).Further,after the treatment,the level of serum miR-140 in the study group was higher than that in the control group,the level of miR-365 was lower than that in the control

关 键 词：膝骨关节炎 富血小板血浆 氨糖美辛肠溶片 关节功能 炎性因子 关节滑液基质 

分 类 号：R684.3[医药卫生—骨科学]