亮丙瑞林联合左炔诺孕酮宫内释放系统治疗子宫腺肌病患者的效果  

Effects of Leuprorelin combined with Levonorgestrel-releasing intrauterine system in treatment of patients with adenomyosis

作　　者：李明茹 冯英 LI Mingru;FENG Ying(Department of Obstetrics and Gynecology of Nanyang Santa Maris Maternity Hospital,Nanyang 473000 Henan,China)

机构地区：[1]南阳圣玛妇产医院妇产科,河南南阳473000

出　　处：《中国民康医学》2024年第15期70-72,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察亮丙瑞林联合左炔诺孕酮宫内释放系统治疗子宫腺肌病患者的效果。方法:选取2021年5月至2023年1月该院收治的87例子宫腺肌病患者进行前瞻性研究,按照随机数字表法将其分为对照组43例和观察组44例。对照组采用左炔诺孕酮宫内释放系统治疗,观察组在对照组基础上联合亮丙瑞林治疗,两组均连续治疗6个月。比较两组临床疗效,治疗前后子宫体积、月经量[月经失血图(PBAC)]评分、痛经程度[视觉模拟评分法(VAS)]评分、血清学指标[糖类抗原19-9(CA19-9)、糖类抗原125(CA125)、前列腺素F2α(PGF2α)]水平,以及不良反应发生率。结果:观察组治疗总有效率为97.73%(43/44),高于对照组的81.40%(35/43),差异有统计学意义(P<0.05);治疗后,观察组子宫体积小于对照组,PBAC和VAS评分低于对照组,差异均有统计学意义(P<0.05);治疗后,观察组CA19-9、CA125、PGF2α水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:亮丙瑞林联合左炔诺孕酮宫内释放系统治疗子宫腺肌病患者可提高治疗总有效率,缩小子宫体积,降低月经量、痛经程度评分和血清学指标水平,效果优于单纯左炔诺孕酮宫内释放系统治疗。Objective:To observe the effect of leuprolide combined with Levonorgestrel-releasing intrauterine system in the treatment of patients with adenomyosis.Methods:A prospective study was conducted on 87 patients with adenomyosis admitted to the hospital from May 2021 to January 2023.According to the random number table method,they were divided into control group(43 cases)and observation group(44 cases).The control group was treated with Levonorgestrel-releasing intrauterine system,while the observation group was treated with Leuprorelin on the basis of that of the control group.Both groups were treated continuously for 6 months.The clinical efficacy,the uterine volume,the menstrual volume[pictorial blood loss assessment chart(PBAC)],the dysmenorrhea[visual analogue scale(VAS)]score,the serological indexes[carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 125(CA125),prostaglandin F2α(PGF2α)]levels before and after the treatment,and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 97.73%(43/44),which was higher than 81.40%(35/43)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the uterine volume of the observation group was smaller than that of the control group,the PBAC and VAS scores were lower than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CA19-9,CA125 and PGF2αin the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Leuprorelin combined with Levonorgestrel-releasing intrauterine system in the treatment of adenomyosis can improve the total effective rate of treatment,reduce the uterine volume and reduce the menstrual volume,the dysmenorrhea scores and the serological index levels.Moreover,it is superior to simple

关 键 词：子宫腺肌病 亮丙瑞林 左炔诺孕酮宫内释放系统 子宫体积 月经量 痛经 血清学 

分 类 号：R711.74[医药卫生—妇产科学]