天麻钩藤汤联合非洛地平缓释片治疗肝阳上亢型原发性高血压患者的效果  

Effects of Tianma Gouteng decoction combined with Felodipine sustained release tablets in treatment of patients with essential hypertension of liver yang hyperactivity type

作　　者：李维云 LI Weiyun(3^(rd) Henan Department of Internal Medicine of Traditional Chinese Medicine Hospital of Henan(Zhengzhou)Institute of Modern Medicine,Zhengzhou 450000 Henan,China)

机构地区：[1]河南(郑州)现代医学研究院中医院内三科,河南郑州450000

出　　处：《中国民康医学》2024年第15期94-97,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察天麻钩藤汤联合非洛地平缓释片治疗肝阳上亢型原发性高血压(EH)的效果。方法:选取2021年6月至2023年6月该院收治的100例肝阳上亢型EH患者进行前瞻性研究,按随机数字表法将其分为观察组与对照组各50例。对照组采用非洛地平缓释片治疗,观察组在对照组基础上联合天麻钩藤汤治疗。比较两组临床疗效,治疗前后血压水平、中医证候积分、血管内皮功能指标[内皮素-1(ET-1)、一氧化氮(NO)]水平,以及不良反应发生率。结果:观察组治疗总有效率为94.00%(47/50),高于对照组的80.00%(40/50),差异有统计学意义(P<0.05);治疗后,两组收缩压、舒张压水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组头晕头痛、烦躁易怒、少寐多梦、口苦口干、便秘等中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组ET-1水平均低于治疗前,且观察组低于对照组,两组NO水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:天麻钩藤汤联合非洛地平缓释片治疗肝阳上亢型EH患者可提高治疗总有效率,改善血管内皮功能指标水平,降低血压水平和中医证候积分,其效果优于单纯非洛地平缓释片治疗。Objective:To observe effects of Tianma Gouteng decoction combined with Felodipine sustained release tablets in treatment of patients with essential hypertension(EH)of liver yang hyperactivity type.Methods:A prospective study was conducted on 100 patients with EH of liver-yang hyperactivity type admitted to the hospital from June 2021 to June 2023.According to the random number table method,they were divided into observation group and control group,50 cases in each group.The control group was treated with Felodipine sustained-release tablets,while the observation group was treated with Tianma Gouteng decoction on the basis of that of the control group.The clinical efficacy,the blood pressure levels,the TCM syndrome scores and the vascular endothelial function index[endothelin-1(ET-1),nitric oxide(NO)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 94.00%(47/50),which was higher than 80.00%(40/50)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of systolic blood pressure and diastolic blood pressure in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as dizziness,headache,irritability,less sleep and more dreams,bitter mouth and dry mouth,and constipation in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of ET-1 in the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;the NO levels of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control

关 键 词：天麻钩藤汤 非洛地平缓释片 肝阳上亢型 原发性高血压 血管内皮功能 血压 不良反应 

分 类 号：R544.1[医药卫生—心血管疾病]