MMP-7对胆道闭锁早期诊断及预后评估价值的研究进展  

Progress on the value of MMP-7 in the early diagnosis and prognosis evaluation of biliary atresia

作　　者：富诗惠 许玲芬[1] Fu Shihui;Xu Lingfen(Department of Pediatric Gastroenterology,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院小儿消化内科,沈阳110004

出　　处：《国际儿科学杂志》2024年第6期377-381,共5页International Journal of Pediatrics

基　　金：国家重点研发计划(2023YFC2706503)。

摘　　要：胆道闭锁是儿童期肝病导致肝移植最主要的病因,Kasai手术是主要的治疗手段,及早确诊、降低手术日龄可改善预后。虽然近年来诊疗水平逐步提高,但是仍有部分患儿最终因肝硬化需肝移植,甚至死亡。目前仍缺少无创的预后评估手段。该文综述了血清基质金属蛋白酶-7(matrix metalloproteinase-7,MMP-7)水平在胆道闭锁早期诊断中的价值,并探讨MMP-7水平与胆道闭锁患儿预后的关系,及MMP-7如何参与胆道闭锁发生发展的机制,为临床诊疗提供参考。Biliary atresia(BA)is the most common cause of liver disease in children leading to liver transplantation.Kasai operation is the main treatment method.Earlier diagnosis and younger age of operation can greatly improve the prognosis.Although the diagnosis and treatment of BA have been gradually improved in recent years,some patients still need liver transplantation or even die due to cirrhosis.There is still a lack of non-invasive prognostic evaluation methods.This article reviews the value of serum matrix metalloproteinase-7(MMP-7)level in the early diagnosis of biliary atresia,and discusses the relationship between MMP-7 level and the prognosis of children with biliary atresia,and how MMP-7 participates in the mechanism of the occurrence and development of biliary atresia,so as to provide reference for clinical diagnosis and treatment.

关 键 词：胆道闭锁 基质金属蛋白酶-7 预后 早期诊断 

分 类 号：R725.7[医药卫生—儿科]