单次大剂量静脉滴注人免疫球蛋白治疗新生儿ABO溶血病的临床效果  

Clinical effect of single high-dose intravenous infusion of Human Immunoglobulin in the treatment of neonatal ABO hemolytic disease

作　　者：仝大鹏 TONG Dapeng(Department of Neonatology,Xianxian Hospital of Traditional Chinese Medicine,Hebei Province,Cangzhou 062250,China)

机构地区：[1]河北省献县中医医院新生儿科,河北沧州062250

出　　处：《妇儿健康导刊》2024年第14期77-80,共4页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

摘　　要：目的探讨单次大剂量静脉滴注人免疫球蛋白治疗新生儿ABO溶血病的临床效果。方法选取2019年1月至2023年6月献县中医医院新生儿科治疗的78例ABO溶血病新生儿作为研究对象,按照抽签法分为A组(39例)与B组(39例)。A组采用单次大剂量静脉滴注人免疫球蛋白治疗,B组采用两次小剂量静脉滴注人免疫球蛋白治疗。比较两组总胆红素(TBil)水平、住院时间、不良反应发生情况及免疫功能。结果治疗24、48、72 h,两组TBil水平均低于治疗前,且A组水平低于B组,差异有统计学意义(P<0.05)。A组住院时间短于B组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。治疗后,两组免疫球蛋白G、免疫球蛋白A水平均升高,且A组水平高于B组(P<0.05)。结论单次大剂量静脉滴注人免疫球蛋白治疗新生儿ABO溶血病效果更好,可提高免疫功能,且不增加不良反应。Objective To explore the clinical effect of single high-dose intravenous infusion of Human Immunoglobulin in the treatment of neonatal ABO hemolytic disease.Methods A total of 78 newborns with neonatal ABO hemolytic disease treated in the Department of Neonatology,Xianxian Hospital of Traditional Chinese Medicine from January 2019 to June 2023 were selected as the study objects.All the newborns were divided into the group A(39 cases)and the group B(39 cases)according to the lottery method.The group A received single high-dose intravenous infusion of Human Immunoglobulin,while the group B received twice low-dose intravenous injections of Human Immunoglobulin.The levels of total bilirubin(TBil),hospitalization time,incidence of adverse reactions,and immune function of the two groups were compared.Results At 24,48,and 72 hours of treatment,the TBil levels in both groups were lower than those before treatment,and the level of the group A was lower than that of the group B,the difference was statistically significant(P<0.05).The hospitalization time of the group A was shorter than that of the group B(P<0.05).After treatment,the levels of immunoglobulin G and immunoglobulin A in both groups were increased,and the levels of the group A were higher than those of the group B(P<0.05).Conclusion Single high-dose intravenous infusion of Human Immunoglobulin is more effective in the treatment of neonatal ABO hemolytic disease,which can improve the immune function without increasing adverse reactions.

关 键 词：新生儿ABO溶血病 静脉滴注人免疫球蛋白 免疫功能 

分 类 号：R722.18[医药卫生—儿科]