丹参酮IIA的稳定性研究进展  

Research Progress on the Stability of Tanshinone IIA

作　　者：于宏博 霍志鹏 冯心池 王晴 Yu Hongbo;Huo Zhipeng;Feng Xinchi;Wang Qing(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;State Key Laboratory of Chinese Medicine Modernization,Tianjin Key Laboratory of Component-Based Chinese Medicine,Tasly Pharmaceutical Group Co.,Ltd.,Tianjin 300410,China;School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,China)

机构地区：[1]天津中医药大学,天津301617 [2]天士力医药集团股份有限公司,现代中药创制全国重点实验室,天津市组分中药重点实验室,天津300410 [3]天津大学药物科学与技术学院,天津300072

出　　处：《化工与医药工程》2024年第4期64-68,共5页Chemical and Pharmaceutical Engineering

摘　　要：丹参酮IIA是丹参中含量最高的脂溶性成分,具有醌类母核、呋喃环、碳碳双键等结构,表现出稳定性差,易降解的特性。文章对影响丹参酮IIA的稳定性因素以及降解机理进行研究总结。结果表明光照、温度、pH值、包合物以及制剂工艺等均能影响丹参酮IIA的稳定性,在强酸及强碱作用下形成一系列降解产物。以期为含丹参酮IIA药物的质量控制和丹参酮IIA的进一步开发利用提供参考。Tanshinone IIA is the most abundant fat-soluble component in Salvia miltiorrhiza,which has the structure of quinone parent nucleus,furan ring and carbon-carbon double bond,exhibiting poor stability and easy degradation.In this paper,the stability factors and degradation mechanisms affecting tanshinone IIA were summarized.The results show that the stability of tanshinone IIA can be affected by light,temperature,pH,envelope and formulation process,and a series of degradation products can be formed under the action of strong acids and bases.In order to provide a reference for the quality control of tanshinone IIA-containing drugs,and the further development and utilization of tanshinone IIA.

关 键 词：丹参酮IIA 稳定性 降解机理 

分 类 号：R283[医药卫生—中药学]