甘草次酸及其衍生物在神经退行性疾病中的防治作用研究进展  

Advancements in research on the preventive and curative roles of glycyrrhetinic acid and its derivatives in neurodegenerative disease

作　　者：刘翼骁 韩欣园 肖依彤 于昕卓 叶田园 LIU Yixiao;HAN Xinyuan;XIAO Yitong;YU Xinzhuo;YE Tianyuan(College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Innovative Institute of Chinese Medicine and Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东中医药大学中医学院,济南250355 [2]山东中医药大学中医药创新研究院,济南250355

出　　处：《中国实验动物学报》2024年第7期923-932,共10页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金(82205078);山东省自然科学基金(ZR2021QH157);山东省中医药科技项目(2021Q079);山东省大学生创新创业训练计划项目(S202310441013,S202310441012)。

摘　　要：随着全球人口老龄化加剧,神经退行性疾病发病率逐年上升,严重影响老年患者的生活质量,给社会带来沉重负担。甘草次酸是中药甘草的主要活性成分之一,具有抑制神经炎症、保护神经元等作用,对于甘草次酸及其衍生物在神经退行性疾病中的作用机制研究日益增多。本研究综述了甘草次酸及其衍生物在阿尔茨海默病、帕金森病、肌萎缩性脊髓侧索硬化症、多发性硬化和小脑萎缩的作用及其机制的研究,并对其未来在神经退行性疾病中的应用进行讨论与展望。The annual incidence of neurodegenerative disease has been increasing with the aging of the global population,seriously affecting the quality of life of elderly patients and imposing a heavy burden on society.Glycyrrhetinic acid,which inhibits neuroinflammation and protects neurons,is one of the main active ingredients of the traditional Chinese medicine Glycyrrhiza glabra.Increasing numbers of studies are focusing on the mechanism of action of glycyrrhetinic acid and its derivatives in neurodegenerative disease.This review summarizes studies on the effects and mechanisms of action of glycyrrhetinic acid and its derivatives in Alzheimer's disease,Parkinson's disease,amyotrophic lateral sclerosis,multiple sclerosis,and cerebellar atrophy.Additionally,the future applications of glycyrrhetinic acid and its derivatives in neurodegenerative disorders are discussed.

关 键 词：甘草次酸 衍生物 作用机制 神经退行性疾病 

分 类 号：Q95-33[生物学—动物学]