Box-Behnken法优化20(S)原人参二醇微囊工艺研究  

Optimization of 20(S)-protopanaxidiol Microcapsules by Box-Behnken Method

作　　者：刘晴 韩晓冉 纪忠娟 司佳 董聪 程祥 李海燕 LIUQing;HANXiaoran;JI Zhongjuan;SI Jia;Dong Cong;CHENG Xiang;LI Haiyan(School of Pharmacy,Jilin University,Changchun 130021,China;The affiliated hospital of Changchun university of Chinese medicine,Changchun 130021,China)

机构地区：[1]吉林大学药学院,吉林长春130021 [2]长春中医药大学附属医院,吉林长春130021

出　　处：《特产研究》2024年第4期143-149,共7页Special Wild Economic Animal and Plant Research

基　　金：黄芪葛根颗粒的开发项目(20210401124YY)。

摘　　要：为优化20(S)-PPD微囊的制备工艺。本研究先通过单因素试验,确定对20(S)-PPD微囊的制备有显著影响的三个因素,分别为转速、加水体积及壁芯比,然后将三个因素分别设置不同的水平,采用Box-Behnken响应面法对制备工艺进行优化,应用Design-Expert 10软件分析试验结果。试验结果表明,20(S)-PPD微囊的最佳制备工艺为壁材比芯材为1.17,即2 g:1.72 g,加水量为74 mL,搅拌分散转速为209 r/min,优化后的制备工艺制备的微囊包封率可达51.05%,与预测值52.77%相接近,且微囊颗粒圆整,大小均匀。运用单因素实验结合Box-Behnken响应面法优化20(S)-PPD的制备工艺,经试验证明后显示结果准确可靠,可行。This study aims to optimize the preparation technology of 20(S)-PPD microcapsules.Three significant factors influencing the preparation of 20(S)-PPD microcapsules were determined through single-factor experiments,namely rotational speed,water volume,and wall-to-core ratio.These factors were then set at different levels,and the Box-Behnken response surface method was employed to optimize the preparation process.The experimental results were analyzed using Design-Expert 10 software.The optimal preparation technology for 20(S)-PPD microcapsules was found to be a wall material to core material ratio of 1.17(2 g:1.72 g).The encapsulation rate of the microcapsules prepared using this optimized process reached 51.05%,close to the predicted value of 52.77%.Additionally,the microcapsules exhibited round and uniform size with an addition of 74 mL water at a rotational speed of 208r/min.The combination of single-factor experiments and Box-Behnken response surface method proved accurate,reliable,and feasible in optimizing the preparation process for 20(S)-PPD.

关 键 词：20(S)-原人参二醇 微囊 制备工艺 Box-Behnken响应面法 

分 类 号：R283.3[医药卫生—中药学]