甘草防治阿尔茨海默病的作用机制研究进展  

Research Progress on the Mechanismof Licorice Intervention on Alzheimer's Disease

作　　者：陈宁 王贞妮[1,2] 刘冰 王冬雪 孙小情 马江涛 CHENNing;WANG Zhenni;LIUBing;WANG Dongxue;SUNXiaoqing;MA Jiangtao(Pharmaceutical Engineering Technology Research Center,Harbin University of Commerce,Harbin 150076,China;Engineering Research Center of Natural Drugs,Minitry of Education,Harbin 150076,China)

机构地区：[1]哈尔滨商业大学药物工程技术研究中心,黑龙江哈尔滨150076 [2]国家教育部抗肿瘤天然药物工程研究中心,黑龙江哈尔滨150076

出　　处：《特产研究》2024年第4期168-174,190,共8页Special Wild Economic Animal and Plant Research

基　　金：黑龙江省自然科学基金优秀青年项目(YQ2021H003)。

摘　　要：阿尔茨海默病(Alzheimer's disease,AD)是一种中枢神经系统退行性疾病,临床表现为学习记忆障碍以及日常生活能力减退等,对老年人的健康造成巨大威胁。近些年,对中药治疗AD的研究逐渐兴盛起来,其具有多组分、多途径、多靶点整体调节以及安全性高,毒副作用小等特点,符合疾病的复杂性需求。甘草作为我国传统药食同源补益类中草药具有抗病毒、抗氧化、抗炎等多种药理活性。研究表明,甘草对AD具有潜在的治疗作用,但其作用机制尚不清晰。研究发现,甘草提取物可以通过抗炎、抗氧化应激,抑制Tau蛋白磷酸化的作用,进而发挥抗AD的作用,甘草单体活性成分及其复方不仅可以通过上述机制达到抗AD的作用,而且能通过抑制β-淀粉样蛋白沉积,保护胆碱能神经元,抑制神经细胞凋亡等达到防治AD的目的。本文就近年来甘草提取物、甘草单体活性成分及甘草复方防治AD的作用机制进行总结,以期为甘草防治AD提供理论依据。Alzheimer's disease(AD)is a degenerative disease of the central nervous system.Its clinical manifestations such as learning and memory disorders and decreased daily living abilities,posing a huge threat to the health of the elderly.In recent years,the research on the treatment of AD with traditional Chinese medicine has gradually flourished.It has the characteristics of multi-component,multi-channel,multi-target overall regulation,high safety,lowtoxicity and side effects,and meets the complex needs of diseases.Glycyrrhiza uralensis,as a traditional Chinese herbal medicine with the same source of food and medicine,has various pharmacological activities such as antiviral,antioxidant,and anti-inflammatory effects.The research has found that licorice extract can exert anti ADeffects by anti-inflammatory,antioxidant stress,and inhibiting Tau protein phosphorylation.The active components of licorice monomers and their compounds can not only achieve anti AD effects through the above mechanisms,but also through inhibition the deposition of β-amyloid protein,the protection of cholinergic neurons,and the inhibition of neuronal apoptosis are all aimed at preventing and treating AD.This study reviews the effective extract of licorice the active components of licorice monomers and the mechanismof licorice in preventing and treating ADin recent years,in order to provide theoretical basis for licorice in preventing and treating AD.

关 键 词：阿尔兹海默病 甘草 作用机制 甘草提取物 甘草素 异甘草素 甘草苷 

分 类 号：R285[医药卫生—中药学]