卡前列素氨丁三醇注射液不同时机给药对瘢痕子宫患者再次剖宫产术后出血的预防效果  

Preventive effect of carboprost tromethamine injection at different times on bleeding after cesarean section in patients with scar uterus

作　　者：陈玲[1] 曾翠英 CHEN Ling;ZENG Cuiying(Department of Obstetrics,Fengcheng People's Hospital,Yichun,Jiangxi,331100,China)

机构地区：[1]丰城市人民医院产科,江西宜春331100

出　　处：《当代医学》2024年第12期40-44,共5页Contemporary Medicine

摘　　要：目的探究卡前列素氨丁三醇注射液不同时机给药对瘢痕子宫患者再次剖宫产术后出血的预防效果。方法选取2019年1月至2022年5月丰城市人民医院收治的80例瘢痕子宫再次剖宫产患者作为研究对象,采用随机数字表法分为A组与B组,每组40例。A组在宫缩乏力时给予卡前列素氨丁三醇注射液,B组在胎儿娩出后即刻给予卡前列素氨丁三醇注射液。比较两组产后出血量、血流动力学指标[心率(HR)、平均动脉压(MAP)]、凝血功能[D-二聚体(D-D)、纤溶酶-抗纤溶酶复合物(PAP)、凝血酶-抗凝血酶复合物(TAT)、纤维蛋白原(Fg)]、康复时间及不良反应发生情况。结果术中及术后2、24h,B组出血量均少于A组,差异有统计学意义(P<0.05)。术后24h时,B组HR水平低于A组,MAP水平高于A组,差异有统计学意义(P<0.05)。术后24h时,B组D-D、PAP、Fg水平均低于A组,TAT水平高于A组,差异有统计学意义(P<0.05)。B组肛门排气时间、排便时间、下床时间、住院时间均短于A组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论在瘢痕子宫患者再次剖宫产术胎儿娩出后即刻给予卡前列素氨丁三醇注射液,可减少产后出血量,缩短术后康复时间,且不增加不良反应发生,值得临床推广应用。Objective To investigate the effect of carboprost tromethamine injection at different times on bleeding after cesarean section in pa-tients with scar uterus.Methods 80 patients with cicatricial uterus undergoing cesarean section in Fengcheng People's Hospital of Jiangxi from Jan-uary 2019 to May 2022 were selected as the research subjects,they were divided into the group A and the group B by random number table method,with 40 cases in each group.Group A was given carboprost tromethamine injection at the time of uterine weakness,and group B was given carbo-prost tromethamine injection immediately after delivery.The postpartum blood loss,hemodynamic indexes(heart rate[HR],mean arterial pressure[MAP]),coagulation function(D-dimer[D-D],plasminase-antiplasminase complex[PAP],thrombinase-antithrombin complex[TAT],fibrinogen[Fg]),recovery time and adverse reactions were compared between the two groups.Results During operation,2 and 24 h after operation,the blood loss in the group B were less than those in the group A,and the differences were statistically significant(P<0.05).24 h after operation,the HR level in the group B was lower than that in the group A,and the MAP level was higher than that in the group A,and the differences were statistically signif-icant(P<0.05).24 h after operation,the level of D-D,PAP and Fg in the group B was lower than those in the group A,and the level of TAT was high-er than that in the group A,and the differences were statistically significant(P<0.05).Anal exhaust time,defecation time,getting out of bed time and hospitalization time in the group B were shorter than those in the group A,and the differences were statistically significant(P<0.05).There was no sig-nificant difference in the total incidence of adverse reactions between the two groups.Conclusion In patients with scarred uterus,immediate adminis-tration of the carboprost tromethamine injection after the delivery of the fetus,can reduce the amount of postpartum bleeding,shorten the postopera-tive rehabilitation time,and do not inc

关 键 词：瘢痕子宫 卡前列素氨丁三醇 给药时机 

分 类 号：R719.8[医药卫生—妇产科学]