术前外周血指标检测在肺部结节良恶性诊断中的应用价值  

Application value of preoperative peripheral blood index detection in diagnosis of benign and malignant pulmonary nodules

作　　者：谢友琴 朱文 谢海琴 XIE Youqin;ZHUWen;XIE Haiqin(Department of Respiratory Medicine,Nantong First People's Hospital,Nantong,Jiangsu,226001,China)

机构地区：[1]南通市第一人民医院肿瘤科,江苏南通226001

出　　处：《当代医学》2024年第12期160-163,共4页Contemporary Medicine

摘　　要：目的探讨术前外周血中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)、乳酸脱氢酶(LDH)检测在肺部结节良恶性诊断中的应用价值。方法回顾性分析2020年1月至2020年12月于南通市第一人民医院胸外科行手术治疗的113例肺部结节患者的临床资料,分析患者的临床病理特征,绘制ROC曲线分析NLR、PLR、LDH对肺部结节良恶性的诊断价值,分析NPL(NLR、PLR、LDH)评分与患者性别、吸烟、病理结果、年龄的关系,分析肺部结节良恶性与患者性别、吸烟、年龄的关系。结果113例肺部结节患者中,病理检查检出良性结节17例,恶性结节96例。NLR诊断肺部结节良恶性的最佳临界值为2.635,AUC为0.757,灵敏度为0.719,特异度为0.706;PLR诊断肺部结节良恶性的最佳临界值为114.9,AUC为0.693,灵敏度为0.74,特异度为0.588。LDH诊断肺部结节良恶性的最佳临界值为189.5 IU/L,AUC为0.828,灵敏度为0.896,特异度为0.647。不同性别、吸烟史、年龄患者NPL评分情况比较差异无统计学意义;肺部结节恶性患者NPL评分高于肺部结节良性患者,差异有统计学意义(P<0.05)。>62岁患者恶性结节比例高于≤62岁患者,差异有统计学意义(P<0.05);不同性别、吸烟史肺部结节良恶性比例比较差异无统计学意义。结论NLR、PLR、LDH对诊断肺部结节良恶性有一定诊断价值,且年龄较大、NPL评分较高,可能对肺部恶性结节有一定的提示价值。Objective To investigate the value of preoperative peripheral blood index neutrophil-lymphocyte ratio(NLR),platelet-lymphocyte ratio(PLR)and lactate dehydrogenase(LDH)in the diagnosis of benign and malignant pulmonary nodules.Methods The clinical data of 113 pa-tients with pulmonary nodules who were operated in the department of Thoracic Surgery of Nantong First People's Hospital from January 1,2020 to December 31,2020 were retrospectively analyzed,and clinicopathological characteristics of patients were analyzed,ROC curve was drawn to ana-lyze the diagnostic value of NLR,PLR and LDH in benign and malignant pulmonary nodules,the relationship between NPL(NLR,PLR,LDH)score and gender,smoking history,pathological results,age of patients was analyzed,the relationship between benign and malignant pulmonary nodules and gender,smoking and age were analyzed.Results Among the 13 pulmonary nodules,17 benign nodules and 96 malignant nodules were detected by pathological examination.The optimal critical value of NLR for the diagnosis of benign and malignant pulmonary nodules was 2.635,AUC was 0.757,sensitivity was 0.719,and specificity was 0.706;the optimal critical value of PLR for the diagnosis of benign and malignant pulmonary nod-ules was 114.9,AUC was 0.693,sensitivity was 0.74,and specificity was 0.588;the optimal critical value of LDH for the diagnosis of benign and ma-lignant pulmonary nodules was 189.5 IU/L,AUC was 0.828,sensitivity was 0.896,and specificity was 0.647.There was no significant difference in NPL score among patients with different gender,smoking history and age;the NPL score of malignant pulmonary nodules was higher than that of be-nign pulmonary nodules,and the difference was statistically significant(P<0.05).The proportion of malignant nodules in patients>62 years old was higher than that in patients≤62 years old,the difference was statistically significant(P<0.05);there was no significant difference in the propor-tion of benign and malignant pulmonary nodules between different genders and smoking

关 键 词：中性粒细胞计数/淋巴细胞计数比值 血小板计数/淋巴细胞计数比值 乳酸脱氢酶 肺结节 

分 类 号：R445.1[医药卫生—影像医学与核医学]