醒神开窍针法联合亚低温疗法对重型颅脑损伤术后康复情况的影响研究  

Study on the effect of Xingshen Kaiqiao acupuncture combined with mild hypothermia therapy on postoperative rehabilitation after severe craniocerebral injury

作　　者：张丽[1] 姚依钵 ZHANG Li;YAO Yi-bo

机构地区：[1]南阳医学高等专科学校第一附属医院神经内科,河南南阳473000 [2]南阳市第一人民医院神经内科,河南南阳473000

出　　处：《中国疗养医学》2024年第9期24-28,共5页Chinese Journal of Convalescent Medicine

基　　金：河南省医学科技攻关项目(LHGJ2021001143)。

摘　　要：目的观察醒神开窍针法联合亚低温疗法对重型颅脑损伤术后康复情况的影响。方法本研究为前瞻性研究,选取南阳医学高等专科学校第一附属医院2021年1月至2023年8月收治的90例重型颅脑损伤患者为研究对象。按照随机数字表将入组患者分别列为亚低温组和联合组,每组各45例。亚低温组实施亚低温疗法辅助治疗,联合组采用醒神开窍针法联合亚低温疗法治疗,比较两组患者的炎症因子、氧化应激指标、神经功能及预后情况。结果在不同治疗方案下,联合组的白细胞介素-8(IL-8)、单核细胞趋化蛋白-1(MCP-1)、超敏C-反应蛋白(hs-CRP)均低于亚低温组;联合组的超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)均高于亚低温组,丙二醛(MDA)低于亚低温组;联合组的半乳糖凝集素3(Galectin-3)、粒细胞巨噬细胞-集落刺激因子(GM-CSF)、神经肽Y(NPY)分别为(5.44±1.25)μg/L、(8.36±1.47)×10^(3)/mm^(3)、(187.43±20.32)pg/mL,均低于亚低温组(6.33±1.52)μg/L、(10.36±2.27)×10^(3)/mm^(3)、(201.38±20.55)pg/mL;联合组的格拉斯哥预后指数(GOS)(4.52±1.25)分高于亚低温组(3.75±0.83)分,改良Fisher量表(mFS)评分(1.32±0.21)分低于亚低温组(2.33±0.82)分,差异均具有统计学意义(P<0.05)。结论醒神开窍针法联合亚低温疗法能缓解重型颅脑损伤患者的炎症反应及氧化应激损伤,对改善患者神经功能及预后情况均有积极意义。Objective To observe the effect of Xingshen Kaiqiao acupuncture combined with mild hypothermia therapy on postoperative rehabilitation after severe craniocerebral injury.Methods This study was a prospective study,and 90 patients with severe craniocerebral injury admitted to the First Affiliated Hospital of Nanyang Medical College from January 2021 to August 2023 were selected as the study objects.The enrolled patients were divided into mild hypothermia group and combined group with 45 cases in each group.The mild hypothermia group was treated with mild hypothermia,and the combined group was treated with Xingshen Kaiqiao acupuncture combined with mild hypothermia.The inflammatory factors,oxidative stress indexes,nerve function and prognosis of the two groups were compared.Results Under different treatment regimens,the levels of interleukin-8(IL-8),monocyte chemotactic protein-1(MCP-1)and hypersensitive C-reactive protein(hs-CRP)in the combined group were lower than those in the mild hypothermia group.Superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)in the combined group were higher than those in the mild hypothermia group,and malondialdehyde(MDA)was lower than that in the mild hypothermia group.The levels of Galectin-3,GM-CSF and NPY in the combined group were(5.44±1.25)μg/L,(8.36±1.47)×10^(3)/mm^(3) and(187.43±20.32)pg/mL,respectively,lower than the mild hypothermia group(6.33±1.52)μg/L,(10.36±2.27)×10^(3)/mm^(3),(201.38±20.55)pg/mL.The Glasgow outcome scale(GOS)score(4.52±1.25)in the combined group was higher than that in the mild hypothermia group(3.75±0.83),and the modified Fisher scale(mFS)score(1.32±0.21)was lower than that in the mild hypothermia group(2.33±0.82),with differences of statistical significance(P<0.05).Conclusion Xingshen Kaiqiao acupuncture combined with mild hypothermia therapy can alleviate inflammation and oxidative stress injury in patients with severe craniocerebral injury,and has positive significance in improving the neurological function and prognosis of patient

关 键 词：重型颅脑损伤 亚低温疗法 醒神开窍针法 术后康复 预后情况 

分 类 号：R651.15[医药卫生—外科学]