瑞舒伐他汀钙片联合琥珀酸美托洛尔缓释片治疗冠心病合并心律失常的临床疗效  

Clinical effect of rosuvastatin calcium tablets combined with metoprolol succinate sustained-release tablets in the treatment of coronary heart disease complicated with arrhythmia

作　　者：马建菁 马建华 MA Jianjing;MA Jianhua(Department of Pharmacy,Shandong University Qilu Hospital,Jinan 250000,China;不详)

机构地区：[1]山东大学齐鲁医院药剂科,济南市250000 [2]山东省荣军总医院内科,济南市250000

出　　处：《临床合理用药杂志》2024年第22期30-33,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的 观察瑞舒伐他汀钙片联合琥珀酸美托洛尔缓释片治疗冠心病合并心律失常的临床疗效。方法 选取2021年1月—2023年1月山东大学齐鲁医院收治的冠心病合并心律失常患者96例作为研究对象,按照随机数字表法分为观察组和对照组,每组48例。对照组给予琥珀酸美托洛尔缓释片治疗,观察组在对照组治疗的基础上给予瑞舒伐他汀钙片治疗,2组均治疗1个月。比较2组临床疗效,治疗前后心功能指标[左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)]和心律失常发作次数。结果 观察组总有效率为85.42%,高于对照组的54.17%(χ^(2)=11.117,P=0.001)。治疗1个月后,2组LVEDD及LVESD小于治疗前,LVEF高于治疗前,且观察组小于/高于对照组(P<0.01);2组室性期前收缩、房性期前收缩及交界性期前收缩次数少于治疗前,且观察组少于对照组(P<0.01)。结论 瑞舒伐他汀钙片联合琥珀酸美托洛尔缓释片治疗冠心病合并心律失常的临床疗效较好,可有效改善冠状动脉血流,减轻心肌的缺血和缺氧状态,并减少心律失常的发作次数。Objective To observe the clinical effect of rosuvastatin calcium tablets combined with metoprolol succinate-sustained release tablets in the treatment of coronary heart disease complicated with arrhythmia.Methods Ninety-six patients with coronary heart disease complicated with arrhythmia admitted to Shandong University Qilu Hospital from January 2021 to January 2023 were selected as the study objects,and were divided into observation group and control group according to random number table method,with 48 cases in each group.The control group was treated with metoprolol succinate sustained-release tablets,and the observation group was treated with rosuvastatin calcium tablets on the basis of the control group.Both groups were treated for 1 month.The clinical efficacy,cardiac function indexes[left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF)] and the frequency of arrhythmia before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 85.42%,which was higher than that of the control group(54.17%)(χ^(2)=11.117,P=0.001).After 1 month of treatment,LVEDD and LVESD in two groups were lower than before treatment,LVEF was higher than before treatment,and observation group was lower/higher than control group(P<0.01).The frequency of ventricular precontraction,atrial precontraction and borderline precontraction in two groups were less than before treatment,and those in observation group were less than control group(P<0.01).Conclusion Rosuvastatin calcium tablets combined with metoprolol succinate sustained-release tablets have good clinical efficacy in the treatment of coronary heart disease complicated with arrhythmia,effectively improving coronary blood flow,alleviating myocardial ischemia and hypoxia,and reducing the number of arrhythmia attacks.

关 键 词：冠心病 心律失常 瑞舒伐他汀钙片 琥珀酸美托洛尔缓释片 治疗效果 

分 类 号：R541.4[医药卫生—心血管疾病] R541.7[医药卫生—内科学]