茵黄益肠合剂对脾胃虚弱型糖尿病性腹泻患者血糖、血脂及炎性标志物的影响  

Effects of Yinhuang Yichang compound on blood glucose,blood lipids and inflammatory markers in patients with diabetic diarrhoea with weak spleen and stomach

作　　者：陈维军[1] 庞永诚[1] 吕锐萍[1] 阮自良 石天杰 陈蕊 殷丽娟 CHEN Weijun;PANG Yongcheng;LYU Ruiping;RUAN Ziliang;SHI Tianjie;CHEN Rui;YIN Lijuan(Kunming Municipal Hospital of Traditional Chinese Medicine,Kunming 650500,China)

机构地区：[1]昆明市中医医院,650500

出　　处：《临床合理用药杂志》2024年第22期34-36,40,共4页Chinese Journal of Clinical Rational Drug Use

基　　金：昆明市卫生科研项目(2022-03-10-014)。

摘　　要：目的 观察茵黄益肠合剂对脾胃虚弱型糖尿病性腹泻患者血糖、血脂及炎性标志物的影响。方法 选取2022年8月—2023年7月昆明市中医医院收治的脾胃虚弱型糖尿病性腹泻患者60例,按入院时间先后顺序随机分为观察组和对照组各30例。对照组采用西医常规治疗,观察组在对照组的基础上加用茵黄益肠合剂治疗,2组疗程均为14 d。比较2组治疗前后血糖指标[空腹血糖(FPG)、果糖胺(FA)]、血脂指标[总胆固醇(TC)、三酰甘油(TG)]、炎性标志物[C反应蛋白(CRP)、白介素-6(IL-6)、降钙素原(PCT)、血清淀粉样蛋白(SAA)]及不良反应。结果 治疗14 d后,2组血清FPG、FA、TC、TG、CRP、IL-6、PCT及SAA水平较治疗前降低,且观察组血清FPG、TC、TG、CRP、IL-6、PCT水平低于对照组(P<0.05或P<0.01),而2组FA、SAA水平比较差异无统计学意义(P>0.05)。2组整个服药过程中均未发现明显不良反应。结论 茵黄益肠合剂治疗脾胃虚弱型糖尿病性腹泻的效果优于单纯西医治疗,能显著改善血糖、血脂及炎性标志物水平,且未发现明显不良反应,安全性较高。Objective To observe the effect of Yinhuang Yichang compound on blood glucose,blood lipids and inflammatory markers in diabetic diarrhoea patients with weak spleen and stomach.Methods Sixty patients with diabetic diarrhoea with weak spleen and stomach admitted to Kunming Municipal Hospital of Traditional Chinese Medicine from August 2022 to July 2023 were selected,and they were randomly divided into the observation group and the control group according to the order of admission,30 cases in each group.The control group was treated with conventional western medicine,while the observation group was treated with Yinhuang Yichang compound on the basis of the control group,and the course of treatment for both groups was 14 days.The levels of blood glucose indexes(FPG,FA),blood lipid indexes(TC,TG),inflammatory markers(CRP,IL-6,PCT,PCT and SAA) before and after treatment and adverse reactions were compared between the two groups.Results After 14 days of treatment,the levels of serum FPG,FA,TC,TG,CRP,IL-6,PCT and SAA of the two groups were lower than those before treatment,and the levels of serum FPG,TC,TG,CRP,IL-6 and PCT in the observation group were lower than those in the control group(P<0.05 or P<0.01),while there were no statistically significant difference between the FA and SAA levels of the two groups(P>0.05).No obvious adverse reactions were found in both groups during the whole process of drug administration.Conclusion The effect of Yinhuang Yichang compound in the treatment of diabetic diarrhoea with weak spleen and stomach is better than that of western medical treatment alone,and it can significantly reduce the levels of blood glucose,blood lipids,and inflammatory markers,and no obvious adverse reactions were found,and the safety is high.

关 键 词：糖尿病性腹泻 脾胃虚弱型 茵黄益肠合剂 血糖 血脂 炎性标志物 

分 类 号：R259[医药卫生—中西医结合]