玻璃体腔注药结合视网膜激光光凝对糖尿病视网膜病变患者最佳矫正视力及视网膜血流动力学的影响  

Effect of vitreous cavity injection combined with whole retinal laser photocoagulation on best corrected visual acuity and retinal hemodynamics in patients with diabetic retinopathy

作　　者：梁娜 张婉泽 李云飞 贾舒雅 李丽[1] LIANG Na;ZHANG Wanze;LI Yunfei(Department of Ophthalmology,Shijiazhuang People’s Hospital,Hebei,Shijiazhuang 050030,China;不详)

机构地区：[1]河北省石家庄市人民医院,050030 [2]河北医科大学基础医学院

出　　处：《河北医药》2024年第15期2300-2303,2307,共5页Hebei Medical Journal

基　　金：河北省医学科学研究重点课题计划项目(编号:20200157)。

摘　　要：目的 探讨玻璃体腔注药结合视网膜激光光凝对糖尿病视网膜病变患者最佳矫正视力及视网膜血流动力学的影响。方法 选取糖尿病视网膜病变患者80例,随机分为对照组和试验组,每组40例(50眼)。对照组采用视网膜激光光凝治疗,试验组采用玻璃体腔注药结合视网膜激光光凝治疗。结果 治疗前,2组最佳矫正视力无差异(P>0.05);治疗后,试验组最佳矫正视力显著优于对照组(P<0.05)。治疗前,2组视网膜中央动脉血流各项指标无显著差异(P>0.05);治疗后,试验组RI显著低于对照组,EDV、PSV显著高于对照组,差异有统计学意义(P<0.05)。治疗前,2组视网膜黄斑区厚度指标无显著差异(P>0.05)。治疗后,试验组视网膜黄斑区厚度显著低于对照组(P<0.05)。治疗前,对照组中并发症4例,其中出血2例,感染2例,并发症率为10.0%;试验组中并发症1例,其中感染1例,并发症发生率为2.5%,试验组并发症率发生显著低于对照组(P<0.05)。试验组患者满意度为97.5%,对照组患者满意度为87.5%,试验组患者满意度明显高于对照组(P<0.05)。结论 玻璃体腔注药结合视网膜激光光凝治疗糖尿病视网膜病变患者的效果明确,改善最佳矫正视力与视网膜血流动力学指标,降低视网膜黄斑厚度,减少并发症,提高患者满意度,适于在临床推广使用。Objective To investigate the effects of vitreous cavity injection combined with whole retinal laser photocoagulation on best corrected visual acuity(BCVA) and retinal hemodynamics in patients with diabetic retinopathy.Methods A total of 80 patients with diabetic retinopathy in our hospital were randomly divided into control group(n=40,50 eyes) and experimental group(n=40,50 eyes).All patients were treated with whole retinal laser photocoagulation,and those in the experimental group were additionally treated with vitreous cavity injection.The effect was compared between groups.Results Before treatment,there was no significant difference in the BCVA between the two groups(P>0.05).After treatment,the BCVA of the experimental group was significantly better than that of the control group(P<0.05).Before treatment,there was no significant difference in blood flow in central retinal artery between the two groups(P>0.05).After treatment,significantly lower resistive index(RI),and significantly higher end-diastolic velocity(EDV) and peak systolic velocity(PSV) in the experimental group were detected relative to the control group(P<0.05).Before treatment,there was no significant difference in macular retinal thickness between the two groups(P>0.05).After treatment,the macular retinal thickness was significantly lower in the experimental group than that in the control group(P<0.05).There were 4(10%) cases of complications(including 2 cases of bleeding and 2 cases of infection) in the control group and 1(2.5%) case of infection complication in the experimental group,the complication rate of the experimental group was significantly lower than that of the control group(P<0.05).The satisfaction of the experimental group was significantly higher than that in the control group(97.5% vs 87.5%,P<0.05).Conclusion The combination of vitreous cavity injection and whole retinal laser photocoagulation in treating patients with diabetic retinopathy has a significant effect.It can improve BCVA and retinal hemodynamics,reduce macular retina

关 键 词：糖尿病视网膜病变 玻璃体腔注射 全视网膜光凝治疗 安全性 

分 类 号：R587.2[医药卫生—内分泌]