血管内大B细胞淋巴瘤的临床研究进展  

Clinical research progress on intravascular large B-cell lymphoma

作　　者：邵芳斐 刘飞飞(综述) 杨倩倩(审校)[1] SHAO Fangfei;LIU Feifei;YANG Qianqian(Department two of Hematology/Cell Therapy Center,Shaw Hospital Affiliated to Zhejiang University School of Medicine,Hangzhou,Zhejiang 310020,China;Department one of Hematology,Shaw Hospital Affiliated to Zhejiang University School of Medicine,Hangzhou,Zhejiang 310020,China)

机构地区：[1]浙江大学医学院附属邵逸夫医院血液内科二/细胞治疗中心,浙江杭州310020 [2]浙江大学医学院附属邵逸夫医院血液内科一,浙江杭州310020

出　　处：《现代医药卫生》2024年第15期2613-2616,2623,共5页Journal of Modern Medicine & Health

基　　金：国家自然科学基金项目(81870136,82170141);浙江省自然科学基金探索青年项目(LQ22H080009)。

摘　　要：血管内大B细胞淋巴瘤(IVLBCL)是一种极为罕见的淋巴瘤,具有早期诊断率低、死亡率高的特点。目前,IVLBCL的发病机制尚不明确。该文从肿瘤黏附、B细胞受体/核转录因子-κB通路、免疫逃避等方面探讨了IVLBCL发病机制,并对其临床检测、治疗方法进行了综述。Intravascular large B-cell lymphoma(IVLBCL)is an extremely rare type of lymphoma characterized by low early diagnosis rate and high mortality rate.At present,the pathogenesis of IVLBCL is not yet clear.The article explores the pathogenesis of IVLBCL from the perspectives of tumor adhesion,B cell receptor/nuclear transcription factor kappa B pathway,immune evasion,etc.,and reviews its clinical detection and treatment methods.

关 键 词：血管内大B细胞淋巴瘤 发病机制 治疗策略 综述 

分 类 号：R552[医药卫生—血液循环系统疾病]