糖尿病肾病中细胞焦亡发生机制及中医药干预研究进展  

Research progress on mechanism of pyroptosis in diabetes nephropathy and intervention of traditional Chinese medicine

作　　者：李清(综述) 王乐 张晓艳[3] 陈雅婷 张梓茹 赵静(审校)[1] LI Qing;WANG Le;ZHANG Xiaoyan;CHEN Yatin;ZHANG Ziru;ZHAO Jing(College of Integrated Chinese and Western Medicine,Hebei Medical University,Shijiazhuang,Hebei 050017,China;Traditional Chinese Medicine Pharmacology Teaching and Research Office,Hebei University of Traditional Chinese Medicine,Shijiazhuang,Hebei 050200,China;Departments Three Of Spleen And Stomach,Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang,Hebei 050000,China)

机构地区：[1]河北医科大学中西医结合学院,河北石家庄050017 [2]河北中医药大学中药药理教研室,河北石家庄050200 [3]河北省中医院脾胃三科,河北石家庄050000

出　　处：《现代医药卫生》2024年第15期2624-2630,共7页Journal of Modern Medicine & Health

基　　金：河北省中医药管理局项目(2018114);河北省卫生健康委员会医学科学研究课题计划项目(20220970);河北医科大学大学生创新性实验计划项目(USIP2022147,USIP2023122)。

摘　　要：细胞焦亡是糖尿病肾病(DKD)发生发展中的重要环节,其引发的炎症和细胞损伤与肾纤维化、肾小球硬化及肾小管损伤有密切关联。深入研究细胞焦亡和炎性小体信号通路的潜在分子机制可能成为预防和治疗DKD的一种新的途径。中医药防治DKD的临床效果显著,其通过影响细胞焦亡通路发挥保护作用。该文对细胞焦亡与DKD的分子机制研究及中医药干预的研究进展进行了综述,为进一步探索细胞焦亡致病机理及中药治疗DKD提供重要指导。Pyroptosis is an important link in the development of diabetes nephropathy(DKD).The inflammation and cell damage caused by it are closely related to renal fibrosis,glomerulosclerosis and tubular damage.In depth research on the potential molecular mechanisms of pyroptosis and inflammasome signaling pathways may become a new approach for the prevention and treatment of DKD.The clinical effect of traditional Chinese medicine in preventing and treating DKD is significant,as it exerts a protective effect by affecting the cell pyroptosis pathway.The article reviews the molecular mechanisms of cell pyroptosis and DKD,as well as the research progress in traditional Chinese medicine intervention,providing important guidance for further exploration of the pathogenic mechanism of cell pyroptosis and the treatment of DKD with traditional Chinese medicine.

关 键 词：细胞焦亡 糖尿病肾病 中医药 综述 

分 类 号：R587.2[医药卫生—内分泌]