冠状动脉内溶栓在急性心肌梗死冠状动脉高血栓负荷患者中的应用效果探讨  

Application effect of intracoronary thrombolysis in patients with acute myocardial infarction and high intracoronary thrombus burden

作　　者：李枝怀 LI Zhi-huai(Zhejiang Provincial People's Hospital Bijie Hospital(Bijie First People's Hospital),Bijie 551700,China)

机构地区：[1]浙江省人民医院毕节医院(毕节市第一人民医院),551700

出　　处：《中国现代药物应用》2024年第14期88-91,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探究冠状动脉内溶栓在急性心肌梗死冠状动脉高血栓负荷患者中的应用效果。方法选取200例急性心肌梗死冠状动脉高血栓负荷患者,随机分为观察组(常规治疗+冠状动脉内溶栓治疗)、对照组(常规治疗),各100例。比较两组治疗效果、心功能指标[左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室射血分数(LVEF)]改善情况、临床症状评分及术后冠状动脉心肌梗死溶栓治疗实验(TIMI)血流分级。结果观察组总有效率97%高于对照组的80%(P<0.05)。观察组治疗后LVEDD(50.14±3.21)mm、LVESD(45.58±4.06)mm均较对照组的(55.36±3.48)、(50.36±4.69)mm更小,LVEF(55.81±4.41)%较对照组的(50.23±3.56)%更高(P<0.05)。观察组治疗后胸痛评分(4.42±0.74)分、呼吸困难评分(4.57±0.51)分较对照组的(3.15±0.45)、(3.30±0.33)分明显更高(P<0.05)。观察组术后冠状动脉TIMI血流分级情况优于对照组(P<0.05)。结论冠状动脉内溶栓应用在急性心肌梗死冠状动脉高血栓负荷患者中可以获得更加显著的治疗效果,有利于改善心功能,减轻临床症状。Objective To explore the application effect of intracoronary thrombolysis in patients with acute myocardial infarction and high intracoronary thrombus burden.Methods 200 patients with acute myocardial infarction and high intracoronary thrombus burden were randomly divided into an observation group(conventional treatment+high intracoronary thrombus burden)and a control group(conventional treatment),with 100 patients in each group.Both groups were compared in terms of therapeutic effect,improvement of cardiac function indexes[left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF)],clinical symptom score and postoperative thrombolysis in myocardial infarction(TIMI)blood flow classification.Results The total effective rate of the observation group was 97%,which was higher than 80%of control group(P<0.05).After treatment,the observation group had LVEDD of(50.14±3.21)mm and LVESD of(45.58±4.06)mm,which were smaller than(50.36±3.48)and(55.36±4.69)mm in the control group;LVEF was(55.81±4.41)%in the observation group,which was higher than(50.23±3.56)%in the control group(P<0.05).After treatment,the scores of chest pain and dyspnea were(4.42±0.74)and(4.57±0.51)points in the observation group,which were significantly higher than(3.15±0.45)and(3.30±0.33)points in the control group(P<0.05).Postoperative TIMI blood flow classification in the observation group was better than that in the control group(P<0.05).Conclusion Application of intracoronary thrombolysis in patients with high intracoronary thrombus burden and acute myocardial infarction can achieve more significant therapeutic effects,which is beneficial for improving heart function and alleviating clinical symptoms.

关 键 词：冠状动脉内溶栓 急性心肌梗死 冠状动脉高血栓负荷 

分 类 号：R542.22[医药卫生—心血管疾病]