阿托伐他汀治疗老年冠心病的疗效及对患者血脂水平的影响探讨  

The efficacy of atorvastatin on elderly patients with coronary heart disease and its impact on blood lipid levels in patients

作　　者：余碧菁[1] YU Bi-jing(Fuzhou Second Hospital,Fuzhou 350007,China)

机构地区：[1]福州市第二医院,350007

出　　处：《中国现代药物应用》2024年第14期92-95,共4页Chinese Journal of Modern Drug Application

摘　　要：目的分析阿托伐他汀在老年冠心病患者中的治疗价值。方法回顾分析200例老年冠心病患者的临床资料,按照治疗方法不同分为对照组(100例)、试验组(100例)。对照组给予常规治疗,试验组在对照组基础上联合使用阿托伐他汀治疗。对比两组的治疗效果、血脂指标和用药不良反应发生情况。结果治疗后,试验组中仅有4例患者无效,对照组中有13例无效,试验组患者的总有效率96.00%较对照组的87.00%更高(P<0.05)。试验组治疗前总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)分别为(6.26±1.78)、(4.82±1.25)、(3.67±1.05)、(0.76±0.29)mmol/L,治疗后分别为(4.80±1.12)、(2.76±0.75)、(2.68±0.64)、(1.15±0.47)mmol/L;对照组治疗前TC、TG、LDL-C、HDL-C分别为(6.35±1.69)、(4.87±1.36)、(3.72±0.96)、(0.72±0.25)mmol/L,治疗后分别为(5.27±1.34)、(3.10±0.84)、(3.10±0.82)、(0.92±0.41)mmol/L。和治疗前相比,治疗后两组患者的TC、TG、LDL-C降低,HDL-C增高,且试验组各指标优于对照组(P<0.05)。试验组中有6例患者出现不良反应,对照组中有8例出现不良反应,组间比较无明显差异(P>0.05)。结论针对老年冠心病患者,在常规治疗的基础上使用阿托伐他汀能提高疗效,有助于控制血脂水平,用药安全性较高,具有推广价值。Objective To analyze the value of atorvastatin in the treatment of elderly patients with coronary heart disease.Methods A retrospective analysis was made on clinical data of 200 elderly patients with coronary heart disease.According to different treatment methods,they were divided into a control group(100 cases)and an experimental group(100 cases).The control group received routine treatment,while the experimental group received a combination of atorvastatin calcium tablets.The treatment efficacy,blood lipid indicators,and adverse drug reactions were compared between the two groups.Results After treatment,only 4 patients in the experimental group and 13 patients in the control group were ineffective,and the total effective rate was 96.00%in the experimental group,which was higher than 87.00%in the control group(P<0.05).In the experimental group,the total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)were(6.26±1.78),(4.82±1.25),(3.67±1.05)and(0.76±0.29)mmol/L before treatment,and those were(4.80±1.12),(2.76±0.75),(2.68±0.64)and(1.15±0.47)mmol/L after treatment.In the control group,TC,TG,LDL-C and HDL-C were(6.35±1.69),(4.87±1.36),(3.72±0.96)and(0.72±0.25)mmol/L before treatment,and those were(5.27±1.34),(3.10±0.84),(3.10±0.82)and(0.92±0.41)mmol/L after treatment.Compared with before treatment,TC,TG and LDL-C were decreased and HDL-C was increased in the two groups after treatment,and the indexes in the experimental group were better than those in the control group(P<0.05).6 patients in the experimental group had adverse reactions,and 8 patients in the control group had adverse reactions,and there was no significant difference between the groups(P>0.05).Conclusion For elderly patients with coronary heart disease,the use of atorvastatin on the basis of conventional treatment can improve the efficacy,help control blood lipid levels with high drug safety,which has the value of promotion.

关 键 词：冠心病 阿托伐他汀 血脂 不良反应 老年 

分 类 号：R541.4[医药卫生—心血管疾病]