分析盐酸溴己新联合阿奇霉素治疗小儿支原体肺炎的临床效果  

Clinical effect of bromohexine hydrochloride combined with azithromycin in the treatment of mycoplasma pneumonia in children

作　　者：刘伟[1] 荆书光 LIU Wei;JING Shu-guang(Department of Pharmaceutical Dispensing,Liaocheng People's Hospital,Liaocheng 252000,China)

机构地区：[1]聊城市人民医院药品调剂科,252000 [2]聊城市人民医院儿科,252000

出　　处：《中国现代药物应用》2024年第14期102-105,共4页Chinese Journal of Modern Drug Application

摘　　要：目的研究盐酸溴己新联合阿奇霉素治疗小儿支原体肺炎的疗效。方法110例小儿支原体肺炎患儿,按随机数字分组命名为研究组和对照组,每组55例。对照组单一使用阿奇霉素治疗,研究组使用盐酸溴己新联合阿奇霉素治疗。比较两组患儿治疗前后的肺功能指标[用力呼出25%肺活量位气体的瞬间流量(MEF25%)、最大呼气流量(PEF)、第1秒用力呼气容积(FEV1)、用力肺活量(FVC)]及炎症因子指标[白细胞介素-6(IL-6)、白细胞介素-17(IL-17)、降钙素原(PCT)]水平。结果治疗后,研究组PEF、MEF25%、FVC、FEV1分别为(2.95±0.67)L/s、(2.14±0.68)L/s、(2.98±0.45)L、(2.65±0.43)L,均高于对照组的(2.59±0.37)L/s、(1.53±0.35)L/s、(2.47±0.41)L、(2.28±0.41)L(P<0.05)。治疗后,研究组IL-6、IL-17、PCT分别为(17.85±1.51)pg/ml、(6.72±0.18)pg/ml、(0.19±0.05)ng/ml,均低于对照组的(28.63±2.13)pg/ml、(12.43±0.27)pg/ml、(0.33±0.08)ng/ml(P<0.05)。结论小儿支原体肺炎选用盐酸溴己新联合阿奇霉素治疗方案可明显改善患儿的肺功能和血清炎症因子指标,治疗的有效性和安全性均较高,值得进一步的运用与推广。Objective To study the efficacy of bromohexine hydrochloride combined with azithromycin in the treatment of mycoplasma pneumonia in children.Methods 110 children with mycoplasma pneumonia were randomly divided into a study group and a control group,with 55 cases in each group.The control group was treated with azithromycin alone,and the study group was treated with bromohexine hydrochloride and azithromycin.Children in both groups were compared in terms of pulmonary function indexes[maximal expiratory flow at 25%of forced vital capacity(MEF25%),peak expiratory flow(PEF),forced expiratory volume in one second(FEV1),forced vital capacity(FVC)]and inflammatory factors[interleukin-6(IL-6),interleukin-17(IL-17),procalcitonin(PCT)]levels before and after treatment.Results After treatment,PEF,MEF25%,FVC and FEV1 of the study group were(2.95±0.67)L/s,(2.14±0.68)L/s,(2.98±0.45)L and(2.65±0.43)L,which were higher than(2.59±0.37)L/s,(1.53±0.35)L/s,(2.47±0.41)L and(2.28±0.41)L of the control group(P<0.05).After treatment,IL-6,IL-17 and PCT in the study group were(17.85±1.51)pg/ml,(6.72±0.18)pg/ml and(0.19±0.05)ng/ml,which were lower than(28.63±2.13)pg/ml,(12.43±0.27)pg/ml and(0.33±0.08)ng/ml in the control group(P<0.05).Conclusion The combination of bromohexine hydrochloride and azithromycin can significantly improve the lung function and serum inflammatory factors of children with mycoplasma pneumonia,and the efficacy and safety of treatment are high,which is worthy of further application and promotion.

关 键 词：盐酸溴己新 阿奇霉素 小儿支原体肺炎 肺功能 血清炎症因子 

分 类 号：R725.6[医药卫生—儿科]